Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 421785..422551 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag FY484_RS16440 Protein ID WP_000982260.1
Coordinates 421785..422282 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag FY484_RS16445 Protein ID WP_000246253.1
Coordinates 422279..422551 (-) Length 91 a.a.

Genomic Context

FY484_RS16390FY484_RS16395FY484_RS16400FY484_RS16405FY484_RS16410FY484_RS16415FY484_RS16420FY484_RS16425FY484_RS16430FY484_RS16450FY484_RS16455FY484_RS16460FY484_RS19570FY484_RS16470FY484_RS16480FY484_RS16485FY484_RS16490FY484_RS16440FY484_RS16445
Location: 417647..417953 (307 bp)
Type: Others
Protein ID: Protein_446
Location: 418090..418782 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 418782..419183 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419153..419296 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419371..419784 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 419998..420249 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420239..420526 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 420654..421109 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421431..421583 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 422782..423450 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 423602..423889 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424030..424401 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424468..424893 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 424890..425423 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 425625..425882 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 425870..426172 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 426406..427323 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 421785..422282 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 422279..422551 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FY484_RS16390417647..417953+307Protein_446CatB-related O-acetyltransferase-
FY484_RS16395418090..418782+693WP_001047169.1GNAT family N-acetyltransferase-
FY484_RS16400418782..419183+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
FY484_RS16405419153..419296+144WP_071908341.1DUF3265 domain-containing protein-
FY484_RS16410419371..419784+414WP_000049417.1VOC family protein-
FY484_RS16415419998..420249+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FY484_RS16420420239..420526+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
FY484_RS16425420654..421109+456WP_001245327.1GNAT family N-acetyltransferase-
FY484_RS16430421431..421583+153WP_001884520.1DUF645 family protein-
FY484_RS16440421785..422282-498WP_000982260.1GNAT family N-acetyltransferaseToxin
FY484_RS16445422279..422551-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
FY484_RS16450422782..423450+669WP_000043871.1hypothetical protein-
FY484_RS16455423602..423889+288WP_000426470.1hypothetical protein-
FY484_RS16460424030..424401+372WP_001164080.1nucleotide pyrophosphohydrolase-
FY484_RS19570424468..424893+426WP_001882332.1DUF1778 domain-containing protein-
FY484_RS16470424890..425423+534WP_000118351.1GNAT family N-acetyltransferase-
FY484_RS16480425625..425882+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FY484_RS16485425870..426172+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
FY484_RS16490426406..427323+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--416599..417579980
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T293804 WP_000982260.1 NZ_LT906615:c422282-421785 [Vibrio cholerae O1 biovar El Tor str. N16961]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT293804 WP_000246253.1 NZ_LT906615:c422551-422279 [Vibrio cholerae O1 biovar El Tor str. N16961]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References