Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365348..365926 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag FY484_RS15830 Protein ID WP_001180243.1
Coordinates 365348..365665 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag FY484_RS15835 Protein ID WP_000557292.1
Coordinates 365684..365926 (-) Length 81 a.a.

Genomic Context

FY484_RS15775FY484_RS15780FY484_RS15785FY484_RS15790FY484_RS15795FY484_RS15800FY484_RS15805FY484_RS15815FY484_RS19515FY484_RS15840FY484_RS15845FY484_RS15850FY484_RS15855FY484_RS15860FY484_RS15865FY484_RS15870FY484_RS19520FY484_RS15885FY484_RS15890FY484_RS15830FY484_RS15835
Location: 360539..360934 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 361237..361418 (182 bp)
Type: Others
Protein ID: Protein_349
Location: 361595..361990 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 362134..362670 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 362967..363146 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 363342..363767 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 363916..364263 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 364410..364703 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 365059..365154 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 366168..366677 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 366734..367387 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 367697..367915 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 368318..368551 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 368976..369156 (181 bp)
Type: Others
Protein ID: Protein_363
Location: 369423..369710 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 369721..370038 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 370035..370145 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 370322..370447 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 370463..370501 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 365348..365665 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 365684..365926 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FY484_RS15775360539..360934+396WP_000046952.1hypothetical protein-
FY484_RS15780361237..361418+182Protein_349DUF645 family protein-
FY484_RS15785361595..361990+396WP_000046953.1hypothetical protein-
FY484_RS15790362134..362670+537WP_000644491.1nucleotidyltransferase family protein-
FY484_RS15795362967..363146+180WP_001883039.1DUF645 family protein-
FY484_RS15800363342..363767+426WP_000403014.1GNAT family N-acetyltransferase-
FY484_RS15805363916..364263+348WP_000933409.1hypothetical protein-
FY484_RS15815364410..364703+294WP_125460920.1hypothetical protein-
FY484_RS19515365059..365154+96WP_001907607.1DUF645 family protein-
FY484_RS15830365348..365665-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FY484_RS15835365684..365926-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
FY484_RS15840366168..366677+510WP_000405987.1GNAT family N-acetyltransferase-
FY484_RS15845366734..367387+654WP_000226874.1hypothetical protein-
FY484_RS15850367697..367915+219WP_001917086.1DUF3709 domain-containing protein-
FY484_RS15855368318..368551+234WP_032482776.1DUF3709 domain-containing protein-
FY484_RS15860368976..369156+181Protein_363DUF645 family protein-
FY484_RS15865369423..369710+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
FY484_RS15870369721..370038+318WP_001232701.1HigA family addiction module antidote protein-
FY484_RS19520370035..370145+111WP_134814058.1DUF3265 domain-containing protein-
FY484_RS15885370322..370447+126WP_001944767.1DUF645 family protein-
FY484_RS15890370463..370501+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T293798 WP_001180243.1 NZ_LT906615:c365665-365348 [Vibrio cholerae O1 biovar El Tor str. N16961]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT293798 WP_000557292.1 NZ_LT906615:c365926-365684 [Vibrio cholerae O1 biovar El Tor str. N16961]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References