Detailed information of TA system TA125049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 967705..968252
• Replicon: chromosome
• Accession: NZ_CP040173
• Organism: Vibrio cholerae strain VC1374

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q9KM92
• Locus tag: FDZ90_RS19290
• Protein ID: WP_000229317.1
• Coordinates: 967950..968252 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: FDZ90_RS19285
• Protein ID: WP_000861987.1
• Coordinates: 967705..967962 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ90_RS19240	962734..963189	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
FDZ90_RS19245	963511..963663	+	153	WP_001884520.1	DUF645 family protein	-
FDZ90_RS19250	963865..964362	-	498	WP_000982260.1	GNAT family N-acetyltransferase	-
FDZ90_RS19255	964359..964631	-	273	WP_000246253.1	DUF1778 domain-containing protein	-
FDZ90_RS19260	964862..965530	+	669	WP_000043871.1	hypothetical protein	-
FDZ90_RS19265	965682..965969	+	288	WP_000426470.1	hypothetical protein	-
FDZ90_RS19270	966110..966481	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
FDZ90_RS19275	966548..966973	+	426	WP_001882332.1	DUF1778 domain-containing protein	-
FDZ90_RS19280	966970..967503	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
FDZ90_RS19285	967705..967962	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FDZ90_RS19290	967950..968252	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FDZ90_RS19295	968486..969403	+	918	WP_000186333.1	alpha/beta hydrolase	-
FDZ90_RS19300	969560..969949	+	390	WP_001081302.1	hypothetical protein	-
FDZ90_RS19305	970085..970294	+	210	Protein_914	GNAT family N-acetyltransferase	-
FDZ90_RS19310	970413..970850	+	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
FDZ90_RS19315	970913..971131	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
FDZ90_RS19320	971306..972178	+	873	WP_000254716.1	DUF3800 domain-containing protein	-
FDZ90_RS19325	972328..972927	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
FDZ90_RS19330	972984..973088	+	105	WP_099607150.1	acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	882589..977840	95251
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	catB9	-	887669..977464	89795
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	970413..970850	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11726.68 Da
• Isoelectric Point: 5.1972

>T125049 WP_000229317.1 NZ_CP040173:967950-968252 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T125049 NZ_CP040173:967950-968252 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT125049 WP_000861987.1 NZ_CP040173:967705-967962 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT125049 NZ_CP040173:967705-967962 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Structures

Toxin

• AlphaFold DB: Q9KM92

Antitoxin

• AlphaFold DB: A0A1T4SLM9