95376

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 50886..51652 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag C4E16_RS14425 Protein ID WP_000982260.1
Coordinates 50886..51383 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag C4E16_RS14430 Protein ID WP_000246253.1
Coordinates 51380..51652 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E16_RS14365 46328..47032 + 705 WP_000087610.1 HNH endonuclease -
C4E16_RS14370 47190..47528 + 339 WP_000713853.1 hypothetical protein -
C4E16_RS14380 47682..47999 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
C4E16_RS14385 48018..48260 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
C4E16_RS14390 48504..48890 + 387 WP_001015867.1 NUDIX hydrolase -
C4E16_RS14395 48947..49060 + 114 WP_001900214.1 hypothetical protein -
C4E16_RS14400 49009..49290 + 282 WP_001894429.1 DUF1289 domain-containing protein -
C4E16_RS14415 49548..50084 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
C4E16_RS14420 50221..50736 + 516 WP_001201509.1 lipocalin family protein -
C4E16_RS14425 50886..51383 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
C4E16_RS14430 51380..51652 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
C4E16_RS14435 52045..52170 + 126 WP_001900195.1 DUF645 family protein -
C4E16_RS19415 52186..52224 + 39 WP_106019118.1 hypothetical protein -
C4E16_RS14445 52420..52866 + 447 WP_000006157.1 hypothetical protein -
C4E16_RS14450 53014..53283 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
C4E16_RS14455 53276..53554 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
C4E16_RS14465 53840..54118 + 279 WP_001921601.1 DUF3709 domain-containing protein -
C4E16_RS19420 54370..54576 + 207 Protein_68 DUF3709 domain-containing protein -
C4E16_RS14470 54776..54877 + 102 WP_001921603.1 hypothetical protein -
C4E16_RS14475 54867..55253 + 387 WP_000703163.1 VOC family protein -
C4E16_RS14480 55448..55699 + 252 WP_001890111.1 TIGR03643 family protein -
C4E16_RS14485 55672..55821 + 150 WP_071908333.1 DUF3265 domain-containing protein -
C4E16_RS14490 55913..56155 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31043..136234 105191
inside Integron - - 36123..135858 99735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T95376 WP_000982260.1 NZ_CP026648:c51383-50886 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T95376 NZ_CP026648:c51383-50886 [Vibrio cholerae O1 biovar El Tor]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT95376 WP_000246253.1 NZ_CP026648:c51652-51380 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT95376 NZ_CP026648:c51652-51380 [Vibrio cholerae O1 biovar El Tor]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References