145844

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 329416..330182 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GTF71_RS14895 Protein ID WP_000982260.1
Coordinates 329416..329913 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GTF71_RS14900 Protein ID WP_000246253.1
Coordinates 329910..330182 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF71_RS14845 324858..325562 + 705 WP_000087610.1 HNH endonuclease -
GTF71_RS14850 325720..326058 + 339 WP_000713853.1 hypothetical protein -
GTF71_RS14855 326212..326529 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF71_RS14860 326548..326790 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF71_RS14865 327034..327420 + 387 WP_001015867.1 NUDIX hydrolase -
GTF71_RS14870 327477..327590 + 114 WP_001900214.1 hypothetical protein -
GTF71_RS14875 327539..327820 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF71_RS14880 327796..327954 - 159 WP_001886450.1 DUF1196 family protein -
GTF71_RS14885 328078..328614 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF71_RS14890 328751..329266 + 516 WP_001201509.1 lipocalin family protein -
GTF71_RS14895 329416..329913 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GTF71_RS14900 329910..330182 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GTF71_RS14905 330575..330700 + 126 WP_001900195.1 DUF645 family protein -
GTF71_RS14910 330716..330754 + 39 WP_106019118.1 hypothetical protein -
GTF71_RS14915 330950..331396 + 447 WP_000006157.1 hypothetical protein -
GTF71_RS14920 331544..331813 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
GTF71_RS14925 331806..332084 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GTF71_RS14930 332370..332648 + 279 WP_001921601.1 DUF3709 domain-containing protein -
GTF71_RS14935 332900..333106 + 207 Protein_297 DUF3709 domain-containing protein -
GTF71_RS14940 333306..333407 + 102 WP_001921603.1 hypothetical protein -
GTF71_RS14945 333397..333783 + 387 WP_000703163.1 VOC family protein -
GTF71_RS14950 333978..334229 + 252 WP_001890111.1 TIGR03643 family protein -
GTF71_RS14955 334202..334351 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF71_RS14960 334443..334685 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306926..439292 132366
inside Integron - - 312006..438916 126910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145844 WP_000982260.1 NZ_CP047300:c329913-329416 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145844 NZ_CP062702:3043598-3043705 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145844 WP_000246253.1 NZ_CP047300:c330182-329910 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145844 NZ_CP062702:c3043550-3043491 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References