104337

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 328886..329426 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag A1552VC_RS15795 Protein ID WP_000277238.1
Coordinates 328886..329155 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag A1552VC_RS15800 Protein ID WP_001258569.1
Coordinates 329148..329426 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1552VC_RS15725 323890..324132 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A1552VC_RS15730 324376..324762 + 387 WP_001015867.1 NUDIX hydrolase -
A1552VC_RS15735 324819..324932 + 114 WP_001900214.1 hypothetical protein -
A1552VC_RS15740 324881..325162 + 282 WP_001894429.1 DUF1289 domain-containing protein -
A1552VC_RS15755 325420..325956 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
A1552VC_RS15760 326093..326608 + 516 WP_001201509.1 lipocalin family protein -
A1552VC_RS15765 326758..327255 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
A1552VC_RS15770 327252..327524 - 273 WP_000246253.1 DUF1778 domain-containing protein -
A1552VC_RS15775 327917..328042 + 126 WP_001900195.1 DUF645 family protein -
A1552VC_RS15780 328058..328096 + 39 WP_106019118.1 hypothetical protein -
A1552VC_RS15790 328292..328738 + 447 WP_000006157.1 hypothetical protein -
A1552VC_RS15795 328886..329155 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
A1552VC_RS15800 329148..329426 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A1552VC_RS15810 329712..329990 + 279 WP_001921601.1 DUF3709 domain-containing protein -
A1552VC_RS15815 330242..330448 + 207 Protein_292 DUF3709 domain-containing protein -
A1552VC_RS15820 330648..330749 + 102 WP_001921603.1 hypothetical protein -
A1552VC_RS15825 330739..331125 + 387 WP_000703163.1 VOC family protein -
A1552VC_RS15830 331320..331571 + 252 WP_001890111.1 TIGR03643 family protein -
A1552VC_RS15835 331544..331693 + 150 WP_071908333.1 DUF3265 domain-containing protein -
A1552VC_RS15840 331785..332027 + 243 WP_000107461.1 hypothetical protein -
A1552VC_RS15845 332279..332557 + 279 WP_000280324.1 DUF3709 domain-containing protein -
A1552VC_RS20015 332932..333075 + 144 Protein_299 DUF645 family protein -
A1552VC_RS20020 333129..333167 + 39 WP_082798268.1 hypothetical protein -
A1552VC_RS15860 333379..333846 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T104337 WP_000277238.1 NZ_CP028895:c329155-328886 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T104337 NZ_CP028895:c329155-328886 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT104337 WP_001258569.1 NZ_CP028895:c329426-329148 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT104337 NZ_CP028895:c329426-329148 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References