Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 328886..329426 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag A1552VC_RS15795 Protein ID WP_000277238.1
Coordinates 328886..329155 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag A1552VC_RS15800 Protein ID WP_001258569.1
Coordinates 329148..329426 (-) Length 93 a.a.

Genomic Context

A1552VC_RS15730A1552VC_RS15735A1552VC_RS15740A1552VC_RS15755A1552VC_RS15760A1552VC_RS15775A1552VC_RS15780A1552VC_RS15790A1552VC_RS15810A1552VC_RS15815A1552VC_RS15820A1552VC_RS15825A1552VC_RS15830A1552VC_RS15835A1552VC_RS15840A1552VC_RS15845A1552VC_RS20015A1552VC_RS20020A1552VC_RS15860A1552VC_RS15725A1552VC_RS15765A1552VC_RS15770A1552VC_RS15795A1552VC_RS15800
Location: 324376..324762 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 324819..324932 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324881..325162 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 325420..325956 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 326093..326608 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 327917..328042 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 328058..328096 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 328292..328738 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 329712..329990 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 330242..330448 (207 bp)
Type: Others
Protein ID: Protein_292
Location: 330648..330749 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 330739..331125 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 331320..331571 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 331544..331693 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 331785..332027 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 332279..332557 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332932..333075 (144 bp)
Type: Others
Protein ID: Protein_299
Location: 333129..333167 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 333379..333846 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 323890..324132 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 326758..327255 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 327252..327524 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 328886..329155 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 329148..329426 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS15725323890..324132-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
A1552VC_RS15730324376..324762+387WP_001015867.1NUDIX hydrolase-
A1552VC_RS15735324819..324932+114WP_001900214.1hypothetical protein-
A1552VC_RS15740324881..325162+282WP_001894429.1DUF1289 domain-containing protein-
A1552VC_RS15755325420..325956+537WP_000469482.1GNAT family N-acetyltransferase-
A1552VC_RS15760326093..326608+516WP_001201509.1lipocalin family protein-
A1552VC_RS15765326758..327255-498WP_000982260.1GNAT family N-acetyltransferase-
A1552VC_RS15770327252..327524-273WP_000246253.1DUF1778 domain-containing protein-
A1552VC_RS15775327917..328042+126WP_001900195.1DUF645 family protein-
A1552VC_RS15780328058..328096+39WP_106019118.1hypothetical protein-
A1552VC_RS15790328292..328738+447WP_000006157.1hypothetical protein-
A1552VC_RS15795328886..329155-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
A1552VC_RS15800329148..329426-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
A1552VC_RS15810329712..329990+279WP_001921601.1DUF3709 domain-containing protein-
A1552VC_RS15815330242..330448+207Protein_292DUF3709 domain-containing protein-
A1552VC_RS15820330648..330749+102WP_001921603.1hypothetical protein-
A1552VC_RS15825330739..331125+387WP_000703163.1VOC family protein-
A1552VC_RS15830331320..331571+252WP_001890111.1TIGR03643 family protein-
A1552VC_RS15835331544..331693+150WP_071908333.1DUF3265 domain-containing protein-
A1552VC_RS15840331785..332027+243WP_000107461.1hypothetical protein-
A1552VC_RS15845332279..332557+279WP_000280324.1DUF3709 domain-containing protein-
A1552VC_RS20015332932..333075+144Protein_299DUF645 family protein-
A1552VC_RS20020333129..333167+39WP_082798268.1hypothetical protein-
A1552VC_RS15860333379..333846+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T104337 WP_000277238.1 NZ_CP028895:c329155-328886 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T104337 NZ_CP028895:c329155-328886 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT104337 WP_001258569.1 NZ_CP028895:c329426-329148 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT104337 NZ_CP028895:c329426-329148 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References