125038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 904560..905100 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag FDZ90_RS18700 Protein ID WP_000277238.1
Coordinates 904560..904829 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag FDZ90_RS18705 Protein ID WP_001258569.1
Coordinates 904822..905100 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ90_RS18645 899565..899807 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FDZ90_RS18650 900051..900437 + 387 WP_001015867.1 NUDIX hydrolase -
FDZ90_RS18655 900494..900607 + 114 WP_001900214.1 hypothetical protein -
FDZ90_RS18660 900556..900837 + 282 WP_001894429.1 DUF1289 domain-containing protein -
FDZ90_RS18665 901095..901631 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
FDZ90_RS18670 901768..902283 + 516 WP_001201509.1 lipocalin family protein -
FDZ90_RS18675 902433..902930 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
FDZ90_RS18680 902927..903199 - 273 WP_000246253.1 DUF1778 domain-containing protein -
FDZ90_RS18685 903592..903717 + 126 WP_001900195.1 DUF645 family protein -
FDZ90_RS18690 903733..903771 + 39 WP_106019118.1 hypothetical protein -
FDZ90_RS18695 903966..904412 + 447 WP_000006157.1 hypothetical protein -
FDZ90_RS18700 904560..904829 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
FDZ90_RS18705 904822..905100 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FDZ90_RS18710 905386..905664 + 279 WP_001921601.1 DUF3709 domain-containing protein -
FDZ90_RS18715 905916..906122 + 207 Protein_796 DUF3709 domain-containing protein -
FDZ90_RS18720 906322..906423 + 102 WP_001921603.1 hypothetical protein -
FDZ90_RS18725 906413..906799 + 387 WP_000703163.1 VOC family protein -
FDZ90_RS18730 906994..907245 + 252 WP_001890111.1 TIGR03643 family protein -
FDZ90_RS18735 907218..907367 + 150 WP_071908333.1 DUF3265 domain-containing protein -
FDZ90_RS18740 907459..907701 + 243 WP_000107461.1 hypothetical protein -
FDZ90_RS18745 907953..908231 + 279 WP_000280324.1 DUF3709 domain-containing protein -
FDZ90_RS18750 908606..908749 + 144 Protein_803 DUF645 family protein -
FDZ90_RS18755 908803..908841 + 39 WP_082798268.1 hypothetical protein -
FDZ90_RS18760 909053..909520 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 882589..977840 95251
inside Integron catB9 - 887669..977464 89795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T125038 WP_000277238.1 NZ_CP040173:c904829-904560 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T125038 NZ_CP040173:c904829-904560 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT125038 WP_001258569.1 NZ_CP040173:c905100-904822 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT125038 NZ_CP040173:c905100-904822 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References