Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 204299..205392 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag ASZ83_RS15465 Protein ID WP_000351248.1
Coordinates 204991..205392 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ83_RS15460 Protein ID WP_001047177.1
Coordinates 204299..204991 (+) Length 231 a.a.

Genomic Context

ASZ83_RS15415ASZ83_RS15420ASZ83_RS20480ASZ83_RS20485ASZ83_RS15440ASZ83_RS15445ASZ83_RS15450ASZ83_RS20210ASZ83_RS15460ASZ83_RS15465ASZ83_RS20215ASZ83_RS15475ASZ83_RS15480ASZ83_RS15485ASZ83_RS15490ASZ83_RS15500ASZ83_RS15515ASZ83_RS15520ASZ83_RS15505ASZ83_RS15510
Location: 199935..200114 (180 bp)
Type: Others
Protein ID: WP_001889238.1
Location: 200308..200823 (516 bp)
Type: Others
Protein ID: WP_000343784.1
Location: 201120..201245 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 201261..201299 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 201512..202516 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 202669..203115 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 203235..204164 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 204161..204271 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 204299..204991 (693 bp)
Type: Antitoxin
Protein ID: WP_001047177.1
Location: 204991..205392 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 205362..205505 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 205580..205993 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 206207..206458 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 206448..206735 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 206863..207318 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 207640..207792 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 208991..209659 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 209811..210098 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 207994..208491 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 208488..208760 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS15415199935..200114+180WP_001889238.1DUF645 family protein-
ASZ83_RS15420200308..200823+516WP_000343784.1GNAT family N-acetyltransferase-
ASZ83_RS20480201120..201245+126WP_001944767.1DUF645 family protein-
ASZ83_RS20485201261..201299+39WP_106019119.1hypothetical protein-
ASZ83_RS15440201512..202516+1005WP_000964925.1LD-carboxypeptidase-
ASZ83_RS15445202669..203115+447WP_000128977.1hypothetical protein-
ASZ83_RS15450203235..204164+930WP_000335802.1hypothetical protein-
ASZ83_RS20210204161..204271+111WP_071917832.1DUF3265 domain-containing protein-
ASZ83_RS15460204299..204991+693WP_001047177.1GNAT family N-acetyltransferaseAntitoxin
ASZ83_RS15465204991..205392+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
ASZ83_RS20215205362..205505+144WP_071908341.1DUF3265 domain-containing protein-
ASZ83_RS15475205580..205993+414WP_000049417.1VOC family protein-
ASZ83_RS15480206207..206458+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ83_RS15485206448..206735+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ83_RS15490206863..207318+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ83_RS15500207640..207792+153WP_001884520.1DUF645 family protein-
ASZ83_RS15505207994..208491-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ83_RS15510208488..208760-273WP_000246253.1DUF1778 domain-containing protein-
ASZ83_RS15515208991..209659+669WP_000043871.1hypothetical protein-
ASZ83_RS15520209811..210098+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T58382 WP_000351248.1 NZ_CP013316:204991-205392 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T58382 NZ_CP013316:204991-205392 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26306.64 Da        Isoelectric Point: 8.6819

>AT58382 WP_001047177.1 NZ_CP013316:204299-204991 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGGPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT58382 NZ_CP013316:204299-204991 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTGGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References