Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 533788..534403 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag ASZ87_RS17195 Protein ID WP_001162670.1
Coordinates 533788..534075 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ87_RS17200 Protein ID WP_001232701.1
Coordinates 534086..534403 (+) Length 106 a.a.

Genomic Context

ASZ87_RS21085ASZ87_RS17165ASZ87_RS17170ASZ87_RS17175ASZ87_RS17185ASZ87_RS17190ASZ87_RS17195ASZ87_RS17200ASZ87_RS21090ASZ87_RS21095ASZ87_RS21100ASZ87_RS17220ASZ87_RS17225ASZ87_RS17230ASZ87_RS17240ASZ87_RS17245ASZ87_RS17155ASZ87_RS17160
Location: 529424..529519 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 530533..531042 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 531099..531752 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 532062..532280 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 532683..532916 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 533341..533521 (181 bp)
Type: Others
Protein ID: Protein_534
Location: 533788..534075 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 534086..534403 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 534400..534510 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 534687..534812 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 534828..534866 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 535090..535830 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 536035..536865 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 536922..537404 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 537851..538726 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 538856..539311 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 529713..530030 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 530049..530291 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS21085529424..529519+96WP_001907607.1DUF645 family protein-
ASZ87_RS17155529713..530030-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ87_RS17160530049..530291-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ87_RS17165530533..531042+510WP_000405987.1GNAT family N-acetyltransferase-
ASZ87_RS17170531099..531752+654WP_000226874.1hypothetical protein-
ASZ87_RS17175532062..532280+219WP_001917086.1DUF3709 domain-containing protein-
ASZ87_RS17185532683..532916+234WP_032482776.1DUF3709 domain-containing protein-
ASZ87_RS17190533341..533521+181Protein_534DUF645 family protein-
ASZ87_RS17195533788..534075+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ87_RS17200534086..534403+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
ASZ87_RS21090534400..534510+111WP_134814058.1DUF3265 domain-containing protein-
ASZ87_RS21095534687..534812+126WP_001944767.1DUF645 family protein-
ASZ87_RS21100534828..534866+39WP_106019119.1hypothetical protein-
ASZ87_RS17220535090..535830+741WP_000469836.1PhzF family phenazine biosynthesis protein-
ASZ87_RS17225536035..536865+831WP_000056616.1abortive infection family protein-
ASZ87_RS17230536922..537404+483WP_001895003.1hypothetical protein-
ASZ87_RS17240537851..538726+876WP_000259044.1hypothetical protein-
ASZ87_RS17245538856..539311+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T58313 WP_001162670.1 NZ_CP013310:533788-534075 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T58313 NZ_CP013310:533788-534075 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT58313 WP_001232701.1 NZ_CP013310:534086-534403 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT58313 NZ_CP013310:534086-534403 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References