113802

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 146944..147577 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag EEL44_RS00765 Protein ID WP_000843587.1
Coordinates 147245..147577 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EEL44_RS00760 Protein ID WP_000071008.1
Coordinates 146944..147258 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS00715 141998..142285 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
EEL44_RS00720 142275..142526 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EEL44_RS00725 142740..143153 - 414 WP_000049417.1 VOC family protein -
EEL44_RS00730 143228..143371 - 144 WP_071908341.1 DUF3265 domain-containing protein -
EEL44_RS00735 143341..143742 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
EEL44_RS00740 143742..144434 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
EEL44_RS00745 144571..144877 - 307 Protein_138 CatB-related O-acetyltransferase -
EEL44_RS00750 144945..145925 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
EEL44_RS20945 146050..146205 - 156 WP_000751734.1 hypothetical protein -
EEL44_RS00755 146373..146807 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
EEL44_RS00760 146944..147258 - 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
EEL44_RS00765 147245..147577 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EEL44_RS00775 147918..148145 - 228 WP_001894457.1 DUF1289 domain-containing protein -
EEL44_RS00780 148094..148207 - 114 WP_001889158.1 hypothetical protein -
EEL44_RS00795 148373..148654 - 282 WP_001894453.1 DUF1289 domain-containing protein -
EEL44_RS21135 148603..148717 - 115 Protein_147 acetyltransferase -
EEL44_RS00800 148774..149151 - 378 WP_000411109.1 hypothetical protein -
EEL44_RS00805 149322..149564 - 243 WP_000107461.1 hypothetical protein -
EEL44_RS00810 149766..150152 - 387 WP_000703163.1 VOC family protein -
EEL44_RS21140 150361..150532 - 172 Protein_151 DUF645 family protein -
EEL44_RS00820 150850..151119 - 270 WP_001198131.1 hypothetical protein -
EEL44_RS00825 151479..151652 - 174 WP_001882305.1 DUF3709 domain-containing protein -
EEL44_RS20960 151933..152136 - 204 WP_001911745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736
flank IS/Tn - - 144945..145925 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T113802 WP_000843587.1 NZ_CP033513:c147577-147245 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T113802 NZ_CP033513:c147577-147245 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT113802 WP_000071008.1 NZ_CP033513:c147258-146944 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT113802 NZ_CP033513:c147258-146944 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References