Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1033164..1033704 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag VCD_RS19485 Protein ID WP_000277238.1
Coordinates 1033435..1033704 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag VCD_RS19480 Protein ID WP_001258569.1
Coordinates 1033164..1033442 (+) Length 93 a.a.

Genomic Context

VCD_RS19480VCD_RS19485VCD_RS19500VCD_RS19505VCD_RS19535VCD_RS19445VCD_RS21090VCD_RS21095VCD_RS19455VCD_RS19460VCD_RS20550VCD_RS19465VCD_RS19470VCD_RS20935VCD_RS20940VCD_RS20560VCD_RS19490VCD_RS20945VCD_RS20795VCD_RS19510VCD_RS19515VCD_RS19525VCD_RS20575VCD_RS19530
Location: 1033164..1033442 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
Location: 1033435..1033704 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 1035066..1035338 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 1035335..1035832 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 1038458..1038700 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 1028744..1029211 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 1029423..1029461 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 1029515..1029658 (144 bp)
Type: Others
Protein ID: Protein_956
Location: 1030033..1030311 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 1030563..1030805 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 1030897..1031046 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 1031019..1031270 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 1031465..1031851 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 1031841..1031942 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 1032142..1032348 (207 bp)
Type: Others
Protein ID: Protein_963
Location: 1032600..1032878 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 1033852..1034298 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 1034494..1034532 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 1034548..1034673 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 1035982..1036497 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 1036634..1037170 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 1037428..1037709 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 1037658..1037771 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 1037828..1038214 (387 bp)
Type: Others
Protein ID: WP_001015867.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCD_RS194451028744..1029211-468WP_001289288.1OsmC family protein-
VCD_RS210901029423..1029461-39WP_082798268.1hypothetical protein-
VCD_RS210951029515..1029658-144Protein_956DUF645 family protein-
VCD_RS194551030033..1030311-279WP_000280324.1DUF3709 domain-containing protein-
VCD_RS194601030563..1030805-243WP_000107461.1hypothetical protein-
VCD_RS205501030897..1031046-150WP_071908333.1DUF3265 domain-containing protein-
VCD_RS194651031019..1031270-252WP_001890111.1TIGR03643 family protein-
VCD_RS194701031465..1031851-387WP_000703163.1VOC family protein-
VCD_RS209351031841..1031942-102WP_001921603.1hypothetical protein-
VCD_RS209401032142..1032348-207Protein_963DUF3709 domain-containing protein-
VCD_RS205601032600..1032878-279WP_001921601.1DUF3709 domain-containing protein-
VCD_RS194801033164..1033442+279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VCD_RS194851033435..1033704+270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
VCD_RS194901033852..1034298-447WP_000006157.1hypothetical protein-
VCD_RS209451034494..1034532-39WP_106019118.1hypothetical protein-
VCD_RS207951034548..1034673-126WP_001900195.1DUF645 family protein-
VCD_RS195001035066..1035338+273WP_000246253.1DUF1778 domain-containing protein-
VCD_RS195051035335..1035832+498WP_000982260.1GNAT family N-acetyltransferase-
VCD_RS195101035982..1036497-516WP_001201509.1lipocalin family protein-
VCD_RS195151036634..1037170-537WP_000469482.1GNAT family N-acetyltransferase-
VCD_RS195251037428..1037709-282WP_001894429.1DUF1289 domain-containing protein-
VCD_RS205751037658..1037771-114WP_001900214.1hypothetical protein-
VCD_RS195301037828..1038214-387WP_001015867.1NUDIX hydrolase-
VCD_RS195351038458..1038700+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932253..1057432125179
insideIntegron--958376..105059692220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T23793 WP_000277238.1 NC_012667:1033435-1033704 [Vibrio cholerae MJ-1236]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T23793 NC_012667:1033435-1033704 [Vibrio cholerae MJ-1236]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT23793 WP_001258569.1 NC_012667:1033164-1033442 [Vibrio cholerae MJ-1236]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT23793 NC_012667:1033164-1033442 [Vibrio cholerae MJ-1236]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References