145838

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 426026..426573 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GTF73_RS16125 Protein ID WP_000229317.1
Coordinates 426271..426573 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GTF73_RS16120 Protein ID WP_000861987.1
Coordinates 426026..426283 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS16075 421055..421510 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GTF73_RS16080 421832..421984 + 153 WP_001884520.1 DUF645 family protein -
GTF73_RS16085 422186..422683 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF73_RS16090 422680..422952 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF73_RS16095 423183..423851 + 669 WP_000043871.1 hypothetical protein -
GTF73_RS16100 424003..424290 + 288 WP_000426470.1 hypothetical protein -
GTF73_RS16105 424431..424802 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GTF73_RS16110 424869..425294 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GTF73_RS16115 425291..425824 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
GTF73_RS16120 426026..426283 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF73_RS16125 426271..426573 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF73_RS16130 426807..427724 + 918 WP_000186333.1 alpha/beta hydrolase -
GTF73_RS16135 427881..428270 + 390 WP_001081302.1 hypothetical protein -
GTF73_RS16140 428406..428615 + 210 Protein_471 GNAT family N-acetyltransferase -
GTF73_RS16145 428734..429171 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTF73_RS16150 429235..429453 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GTF73_RS16155 429628..430500 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GTF73_RS16160 430650..431249 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GTF73_RS16165 431306..431410 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805
flank IS/Tn - - 428734..429171 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145838 WP_000229317.1 NZ_CP047298:426271-426573 [Vibrio cholerae O1 biovar El Tor]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145838 NZ_CP062702:939062-939469 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145838 WP_000861987.1 NZ_CP047298:426026-426283 [Vibrio cholerae O1 biovar El Tor]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145838 NZ_CP062702:938815-939081 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References