145067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 367363..367941 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GPY07_RS16155 Protein ID WP_001180243.1
Coordinates 367624..367941 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GPY07_RS16150 Protein ID WP_000557292.1
Coordinates 367363..367605 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS16100 362788..362826 - 39 WP_106019119.1 hypothetical protein -
GPY07_RS16105 362842..362967 - 126 WP_001944767.1 DUF645 family protein -
GPY07_RS19445 363144..363254 - 111 WP_134814058.1 DUF3265 domain-containing protein -
GPY07_RS16115 363251..363568 - 318 WP_001232701.1 HigA family addiction module antidote protein -
GPY07_RS16120 363579..363866 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY07_RS16125 364133..364313 - 181 Protein_353 DUF645 family protein -
GPY07_RS16130 364738..364971 - 234 WP_032482776.1 DUF3709 domain-containing protein -
GPY07_RS16135 365374..365592 - 219 WP_001917086.1 DUF3709 domain-containing protein -
GPY07_RS16140 365902..366555 - 654 WP_000226874.1 hypothetical protein -
GPY07_RS16145 366612..367121 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
GPY07_RS16150 367363..367605 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY07_RS16155 367624..367941 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY07_RS19450 368135..368230 - 96 WP_001907607.1 DUF645 family protein -
GPY07_RS16165 368586..368879 - 294 WP_125460920.1 hypothetical protein -
GPY07_RS16175 369026..369373 - 348 WP_000933409.1 hypothetical protein -
GPY07_RS16180 369522..369947 - 426 WP_000403014.1 GNAT family N-acetyltransferase -
GPY07_RS16185 370143..370322 - 180 WP_001883039.1 DUF645 family protein -
GPY07_RS16190 370619..371155 - 537 WP_000644491.1 nucleotidyltransferase family protein -
GPY07_RS16195 371299..371694 - 396 WP_000046953.1 hypothetical protein -
GPY07_RS16200 371871..372052 - 182 Protein_367 DUF645 family protein -
GPY07_RS16205 372355..372750 - 396 WP_000046952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145067 WP_001180243.1 NZ_CP046841:367624-367941 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145067 NZ_CP062253:c334714-334400 [Pseudomonas gozinkensis]
ATGATTTTTGTTGAGACTCGGATCTTTACCCGTCGAGTAAAAGAGCTGCTGGACGATGACACGTATGCCGCTTTTCAGAA
GCAACTGGTTGTAAGTCCTTCGATTGGCGATGTAATTGAAGGCACAGGCGGGATCCGCAAAACCCGAATCGCAGCGAAAG
GACACGGCAAGCGAGGCGGAGCACGGGTTATCTACTACCACTTCGTTTCGGCGTCACAAATCGGGTTATTGATGATCTAC
CCTAAAAATGAACAACACGATCTGTCCAGCGATGAGCGTAAAGCACTCAAGGTCTTGATCGAAAAATGGAGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145067 WP_000557292.1 NZ_CP046841:367363-367605 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145067 NZ_CP062253:c334397-334110 [Pseudomonas gozinkensis]
ATGAGCAAATTTTTTGATGAGCTGATGGAAAGTGTGCAAGAGATGGACGAGATCGTACGAGGCGGGCGCACACCTTCTCG
CGAATTCCACGTTGATGCATTGCAGGTCAAAGAAATTCGTAAAGCTACCGGTTTGACCCAGACCAAATTTGCGGCACTGA
TCGACGTCCAACTCGGCACTCTACGAAATTGGGAACAGGGTCGTCGCGAGCCAACCGGGCCGGCAAAAGCTCTGCTCAAG
GCCATTCATAACGACCCGGTTCATGTTTTGAATGCATTGGCCCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References