Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 358082..358697 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag LVJ30_RS15620 Protein ID WP_001162670.1
Coordinates 358082..358369 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LVJ30_RS15625 Protein ID WP_001232701.1
Coordinates 358380..358697 (+) Length 106 a.a.

Genomic Context

LVJ30_RS15560LVJ30_RS15565LVJ30_RS15580LVJ30_RS15585LVJ30_RS15590LVJ30_RS15595LVJ30_RS15600LVJ30_RS15605LVJ30_RS15610LVJ30_RS15615LVJ30_RS15620LVJ30_RS15625LVJ30_RS15630LVJ30_RS15635LVJ30_RS15640LVJ30_RS15645LVJ30_RS15650LVJ30_RS15655LVJ30_RS15660LVJ30_RS15665LVJ30_RS15670LVJ30_RS15675LVJ30_RS15570LVJ30_RS15575
Location: 353425..353600 (176 bp)
Type: Others
Protein ID: Protein_345
Location: 353661..353813 (153 bp)
Type: Others
Protein ID: Protein_346
Location: 354827..355336 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 355393..356046 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 356135..356344 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 356356..356574 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 356763..356956 (194 bp)
Type: Others
Protein ID: Protein_353
Location: 356977..357210 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 357635..357815 (181 bp)
Type: Others
Protein ID: Protein_355
Location: 357928..358041 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 358082..358369 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 358380..358697 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 358694..358804 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 358843..358953 (111 bp)
Type: Others
Protein ID: Protein_360
Location: 358981..359106 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 359069..359185 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 359373..360377 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 360530..360976 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 361096..362025 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 362022..362132 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 362160..362636 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 362827..363288 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 354007..354324 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 354343..354585 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LVJ30_RS15560 (LVJ30_15565)353425..353600+176Protein_345acetyltransferase-
LVJ30_RS15565 (LVJ30_15570)353661..353813+153Protein_346DUF645 family protein-
LVJ30_RS15570 (LVJ30_15575)354007..354324-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
LVJ30_RS15575 (LVJ30_15580)354343..354585-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
LVJ30_RS15580 (LVJ30_15585)354827..355336+510WP_000405987.1GNAT family N-acetyltransferase-
LVJ30_RS15585 (LVJ30_15590)355393..356046+654WP_000226874.1hypothetical protein-
LVJ30_RS15590 (LVJ30_15595)356135..356344+210WP_001900246.1DUF3709 domain-containing protein-
LVJ30_RS15595 (LVJ30_15600)356356..356574+219WP_001917086.1DUF3709 domain-containing protein-
LVJ30_RS15600 (LVJ30_15605)356763..356956+194Protein_353hypothetical protein-
LVJ30_RS15605 (LVJ30_15610)356977..357210+234WP_032482776.1DUF3709 domain-containing protein-
LVJ30_RS15610 (LVJ30_15615)357635..357815+181Protein_355DUF645 family protein-
LVJ30_RS15615 (LVJ30_15620)357928..358041+114WP_001894955.1hypothetical protein-
LVJ30_RS15620 (LVJ30_15625)358082..358369+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LVJ30_RS15625 (LVJ30_15630)358380..358697+318WP_001232701.1HigA family addiction module antitoxinAntitoxin
LVJ30_RS15630 (LVJ30_15635)358694..358804+111WP_134814058.1DUF3265 domain-containing protein-
LVJ30_RS15635 (LVJ30_15640)358843..358953+111Protein_360acetyltransferase-
LVJ30_RS15640 (LVJ30_15645)358981..359106+126WP_001944767.1DUF645 family protein-
LVJ30_RS15645 (LVJ30_15650)359069..359185+117WP_001889170.1hypothetical protein-
LVJ30_RS15650 (LVJ30_15655)359373..360377+1005WP_000964925.1LD-carboxypeptidase-
LVJ30_RS15655 (LVJ30_15660)360530..360976+447WP_000128977.1hypothetical protein-
LVJ30_RS15660 (LVJ30_15665)361096..362025+930WP_000335802.1hypothetical protein-
LVJ30_RS15665 (LVJ30_15670)362022..362132+111WP_071917832.1DUF3265 domain-containing protein-
LVJ30_RS15670 (LVJ30_15675)362160..362636+477WP_001047180.1GNAT family N-acetyltransferase-
LVJ30_RS15675 (LVJ30_15680)362827..363288+462WP_001903091.1lipocalin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T230521 WP_001162670.1 NZ_CP090379:358082-358369 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T230521 NZ_CP124916:c2797458-2797117 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT230521 WP_001232701.1 NZ_CP090379:358380-358697 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT230521 NZ_CP124916:c2797688-2797458 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAACTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References