Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 753024..753808 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag A6J62_RS03395 Protein ID WP_001114075.1
Coordinates 753539..753808 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag A6J62_RS03390 Protein ID WP_000921691.1
Coordinates 753024..753545 (-) Length 174 a.a.

Genomic Context

A6J62_RS03365A6J62_RS03370A6J62_RS03350A6J62_RS03360A6J62_RS03375A6J62_RS03385A6J62_RS03390A6J62_RS03395A6J62_RS03400A6J62_RS03405A6J62_RS03410A6J62_RS03415A6J62_RS03420A6J62_RS03425A6J62_RS03430A6J62_RS03435
Location: 751256..751540 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 751537..751815 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 749950..750363 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 750547..751062 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 751954..752349 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 752600..752725 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 753024..753545 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 753539..753808 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 753839..753943 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 754000..754599 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 754749..755621 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 755796..756014 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 756078..756515 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 756634..756843 (210 bp)
Type: Others
Protein ID: Protein_647
Location: 756979..757368 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 757525..758442 (918 bp)
Type: Others
Protein ID: WP_000186333.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A6J62_RS03350749950..750363-414WP_000049420.1VOC family protein-
A6J62_RS03360750547..751062-516WP_000343779.1GNAT family N-acetyltransferase-
A6J62_RS03365751256..751540+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
A6J62_RS03370751537..751815+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
A6J62_RS03375751954..752349-396WP_001000867.1hypothetical protein-
A6J62_RS03385752600..752725-126WP_001905700.1DUF645 family protein-
A6J62_RS03390753024..753545-522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
A6J62_RS03395753539..753808-270WP_001114075.1DUF4160 domain-containing proteinToxin
A6J62_RS03400753839..753943-105WP_099607150.1acetyltransferase-
A6J62_RS03405754000..754599-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
A6J62_RS03410754749..755621-873WP_000254716.1DUF3800 domain-containing protein-
A6J62_RS03415755796..756014-219WP_071908318.1GNAT family N-acetyltransferase-
A6J62_RS03420756078..756515-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
A6J62_RS03425756634..756843-210Protein_647GNAT family N-acetyltransferase-
A6J62_RS03430756979..757368-390WP_001081302.1hypothetical protein-
A6J62_RS03435757525..758442-918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-749087..881909132822
insideIntegron--749463..875103125640
flankIS/Tn--756078..756515437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T74615 WP_001114075.1 NZ_CP020407:c753808-753539 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T74615 NZ_CP020407:c753808-753539 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT74615 WP_000921691.1 NZ_CP020407:c753545-753024 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT74615 NZ_CP020407:c753545-753024 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References