145069

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 388911..389409 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GPY07_RS16355 Protein ID WP_000589156.1
Coordinates 389143..389409 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GPY07_RS16350 Protein ID WP_000643598.1
Coordinates 388911..389156 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS16305 384401..384580 - 180 WP_001883058.1 DUF645 family protein -
GPY07_RS16315 385158..385268 - 111 WP_079857360.1 DUF3265 domain-containing protein -
GPY07_RS16320 385278..385976 - 699 WP_001890502.1 hypothetical protein -
GPY07_RS16325 386099..386725 - 627 WP_000365424.1 LysE family translocator -
GPY07_RS16330 386767..386859 - 93 WP_014378730.1 DUF3265 domain-containing protein -
GPY07_RS16335 386874..387347 - 474 WP_001161076.1 GrpB family protein -
GPY07_RS16340 387547..387729 - 183 WP_000923182.1 DUF645 family protein -
GPY07_RS19455 387790..387918 - 129 WP_071908338.1 general secretion pathway protein GspI -
GPY07_RS16345 388021..388815 - 795 WP_001911581.1 hypothetical protein -
GPY07_RS16350 388911..389156 - 246 WP_000643598.1 hypothetical protein Antitoxin
GPY07_RS16355 389143..389409 - 267 WP_000589156.1 BrnT family toxin Toxin
GPY07_RS16360 389594..390256 - 663 WP_000960654.1 hypothetical protein -
GPY07_RS16365 390384..390851 - 468 WP_001289288.1 OsmC family protein -
GPY07_RS19460 391063..391101 - 39 WP_082798268.1 hypothetical protein -
GPY07_RS19465 391155..391298 - 144 Protein_400 DUF645 family protein -
GPY07_RS16375 391673..391951 - 279 WP_000280324.1 DUF3709 domain-containing protein -
GPY07_RS16380 392203..392445 - 243 WP_000107461.1 hypothetical protein -
GPY07_RS16385 392537..392686 - 150 WP_071908333.1 DUF3265 domain-containing protein -
GPY07_RS16390 392659..392910 - 252 WP_001890111.1 TIGR03643 family protein -
GPY07_RS16395 393105..393491 - 387 WP_000703163.1 VOC family protein -
GPY07_RS16400 393481..393582 - 102 WP_001921603.1 hypothetical protein -
GPY07_RS16405 393782..393988 - 207 Protein_407 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T145069 WP_000589156.1 NZ_CP046841:c389409-389143 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T145069 NZ_CP062253:c2324049-2323765 [Pseudomonas gozinkensis]
ATGCAGATTAAGTGGCGACCCAAGGCTCGGGTCGAACTCTCGAAAATACTGAAGTACATTGGCGAGCGAAATTTTGTGGC
GGCGACAGCACTTCACAAGCCAGTCGTAAAAACTACATCTGCGCTTCCTTGGCATCCACACCTGTATCGCAAAGGTCGCT
CTCCCGGCACTCGGGAGATTGTGGTTAGCCCGAACTATCTCGTCGTTTATCAAGTGGCGGACCGAATTGAGATTGTGAGC
ATCTTGCATGCGCGTCAGGAATACCCTCGACGCGACCCCAGTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT145069 WP_000643598.1 NZ_CP046841:c389156-388911 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT145069 NZ_CP062253:c2324245-2324039 [Pseudomonas gozinkensis]
ATGATCGACCCGTCTTTGATCGACCCACTGTGCCCGGTTGTTTCGGATCTTGCTCCTGAGGAGCAGGCTGCGAGTTATGA
CCGTTGGTTTCGCGCCGAAGTACAGGCCTCTCTCGATGATCCGCGTCCGAGTATTCCCCATGAGCAAGTGATAGCGGAAA
TAAACGCCTTGATGGAATCAATGCGCAAAAGCGCTGATGCAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References