Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 323911..324677 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag C1H56_RS15740 Protein ID WP_000982260.1
Coordinates 323911..324408 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag C1H56_RS15745 Protein ID WP_000246253.1
Coordinates 324405..324677 (-) Length 91 a.a.

Genomic Context

C1H56_RS15680C1H56_RS15685C1H56_RS15705C1H56_RS15710C1H56_RS15715C1H56_RS15730C1H56_RS15735C1H56_RS15750C1H56_RS19830C1H56_RS15760C1H56_RS15780C1H56_RS19835C1H56_RS15785C1H56_RS15790C1H56_RS15795C1H56_RS15800C1H56_RS15805C1H56_RS15695C1H56_RS15700C1H56_RS15740C1H56_RS15745C1H56_RS15765C1H56_RS15770
Location: 319353..320057 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 320215..320553 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 321529..321915 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 321972..322085 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322034..322315 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 322573..323109 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323246..323761 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 325070..325195 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 325211..325249 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 325445..325891 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 326820..327143 (324 bp)
Type: Others
Protein ID: WP_001883073.1
Location: 327395..327601 (207 bp)
Type: Others
Protein ID: Protein_290
Location: 327801..327902 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 327892..328278 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 328473..328724 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 328697..328846 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 328938..329180 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 320707..321024 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 321043..321285 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 323911..324408 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 324405..324677 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 326039..326308 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 326301..326579 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS15680319353..320057+705WP_000087610.1HNH endonuclease-
C1H56_RS15685320215..320553+339WP_000713853.1hypothetical protein-
C1H56_RS15695320707..321024-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
C1H56_RS15700321043..321285-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C1H56_RS15705321529..321915+387WP_001015867.1NUDIX hydrolase-
C1H56_RS15710321972..322085+114WP_001900214.1hypothetical protein-
C1H56_RS15715322034..322315+282WP_001894429.1DUF1289 domain-containing protein-
C1H56_RS15730322573..323109+537WP_000469482.1GNAT family N-acetyltransferase-
C1H56_RS15735323246..323761+516WP_001201509.1lipocalin family protein-
C1H56_RS15740323911..324408-498WP_000982260.1GNAT family N-acetyltransferaseToxin
C1H56_RS15745324405..324677-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
C1H56_RS15750325070..325195+126WP_001900195.1DUF645 family protein-
C1H56_RS19830325211..325249+39WP_106019118.1hypothetical protein-
C1H56_RS15760325445..325891+447WP_000006157.1hypothetical protein-
C1H56_RS15765326039..326308-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
C1H56_RS15770326301..326579-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
C1H56_RS15780326820..327143+324WP_001883073.1DUF3709 domain-containing protein-
C1H56_RS19835327395..327601+207Protein_290DUF3709 domain-containing protein-
C1H56_RS15785327801..327902+102WP_001921603.1hypothetical protein-
C1H56_RS15790327892..328278+387WP_000703163.1VOC family protein-
C1H56_RS15795328473..328724+252WP_001890111.1TIGR03643 family protein-
C1H56_RS15800328697..328846+150WP_071908333.1DUF3265 domain-containing protein-
C1H56_RS15805328938..329180+243WP_000107461.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T92503 WP_000982260.1 NZ_CP025937:c324408-323911 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T92503 NZ_CP025937:c324408-323911 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT92503 WP_000246253.1 NZ_CP025937:c324677-324405 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT92503 NZ_CP025937:c324677-324405 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

Loading, please wait
Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References