92503

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 323911..324677 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag C1H56_RS15740 Protein ID WP_000982260.1
Coordinates 323911..324408 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag C1H56_RS15745 Protein ID WP_000246253.1
Coordinates 324405..324677 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H56_RS15680 319353..320057 + 705 WP_000087610.1 HNH endonuclease -
C1H56_RS15685 320215..320553 + 339 WP_000713853.1 hypothetical protein -
C1H56_RS15695 320707..321024 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
C1H56_RS15700 321043..321285 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
C1H56_RS15705 321529..321915 + 387 WP_001015867.1 NUDIX hydrolase -
C1H56_RS15710 321972..322085 + 114 WP_001900214.1 hypothetical protein -
C1H56_RS15715 322034..322315 + 282 WP_001894429.1 DUF1289 domain-containing protein -
C1H56_RS15730 322573..323109 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
C1H56_RS15735 323246..323761 + 516 WP_001201509.1 lipocalin family protein -
C1H56_RS15740 323911..324408 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
C1H56_RS15745 324405..324677 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
C1H56_RS15750 325070..325195 + 126 WP_001900195.1 DUF645 family protein -
C1H56_RS19830 325211..325249 + 39 WP_106019118.1 hypothetical protein -
C1H56_RS15760 325445..325891 + 447 WP_000006157.1 hypothetical protein -
C1H56_RS15765 326039..326308 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
C1H56_RS15770 326301..326579 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
C1H56_RS15780 326820..327143 + 324 WP_001883073.1 DUF3709 domain-containing protein -
C1H56_RS19835 327395..327601 + 207 Protein_290 DUF3709 domain-containing protein -
C1H56_RS15785 327801..327902 + 102 WP_001921603.1 hypothetical protein -
C1H56_RS15790 327892..328278 + 387 WP_000703163.1 VOC family protein -
C1H56_RS15795 328473..328724 + 252 WP_001890111.1 TIGR03643 family protein -
C1H56_RS15800 328697..328846 + 150 WP_071908333.1 DUF3265 domain-containing protein -
C1H56_RS15805 328938..329180 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304067..433328 129261
inside Integron catB9 - 309147..432952 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T92503 WP_000982260.1 NZ_CP025937:c324408-323911 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T92503 NZ_CP025937:c324408-323911 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT92503 WP_000246253.1 NZ_CP025937:c324677-324405 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT92503 NZ_CP025937:c324677-324405 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References