Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-Phd |
Location | 354007..354585 | Replicon | chromosome |
Accession | NZ_CP012666 | ||
Organism | Vibrio cholerae strain ICDC-VC661 |
Toxin (Protein)
Gene name | parE | Uniprot ID | O68848 |
Locus tag | AN947_RS01865 | Protein ID | WP_001180243.1 |
Coordinates | 354007..354324 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | Q7DCR7 |
Locus tag | AN947_RS01870 | Protein ID | WP_000557292.1 |
Coordinates | 354343..354585 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AN947_RS01820 | 349423..349593 | + | 171 | WP_001911568.1 | hypothetical protein | - |
AN947_RS01825 | 349896..350077 | + | 182 | Protein_330 | DUF645 family protein | - |
AN947_RS01830 | 350254..350649 | + | 396 | WP_000046953.1 | hypothetical protein | - |
AN947_RS01835 | 350793..351329 | + | 537 | WP_000644491.1 | nucleotidyltransferase family protein | - |
AN947_RS01840 | 351626..351805 | + | 180 | WP_001883039.1 | DUF645 family protein | - |
AN947_RS01845 | 352001..352426 | + | 426 | WP_000403014.1 | GNAT family N-acetyltransferase | - |
AN947_RS01850 | 352575..352922 | + | 348 | WP_000933409.1 | hypothetical protein | - |
AN947_RS20745 | 353069..353362 | + | 294 | WP_125460920.1 | hypothetical protein | - |
AN947_RS20750 | 353718..353813 | + | 96 | WP_001907607.1 | DUF645 family protein | - |
AN947_RS01865 | 354007..354324 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
AN947_RS01870 | 354343..354585 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
AN947_RS01875 | 354827..355336 | + | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
AN947_RS01880 | 355393..356046 | + | 654 | WP_000226874.1 | hypothetical protein | - |
AN947_RS01885 | 356356..356574 | + | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
AN947_RS01895 | 356977..357210 | + | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
AN947_RS01900 | 357635..357815 | + | 181 | Protein_344 | DUF645 family protein | - |
AN947_RS01905 | 358082..358369 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
AN947_RS01910 | 358380..358697 | + | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
AN947_RS20755 | 358694..358804 | + | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
AN947_RS01920 | 358981..359106 | + | 126 | WP_001944767.1 | DUF645 family protein | - |
AN947_RS20760 | 359122..359160 | + | 39 | WP_106019119.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 304645..399892 | 95247 | |
inside | Integron | - | - | 309725..399516 | 89791 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T56914 WP_001180243.1 NZ_CP012666:c354324-354007 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T56914 NZ_CP012666:c354324-354007 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT56914 WP_000557292.1 NZ_CP012666:c354585-354343 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT56914 NZ_CP012666:c354585-354343 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0K9UJR8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q7DCR7 |