56914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 354007..354585 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag AN947_RS01865 Protein ID WP_001180243.1
Coordinates 354007..354324 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag AN947_RS01870 Protein ID WP_000557292.1
Coordinates 354343..354585 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN947_RS01820 349423..349593 + 171 WP_001911568.1 hypothetical protein -
AN947_RS01825 349896..350077 + 182 Protein_330 DUF645 family protein -
AN947_RS01830 350254..350649 + 396 WP_000046953.1 hypothetical protein -
AN947_RS01835 350793..351329 + 537 WP_000644491.1 nucleotidyltransferase family protein -
AN947_RS01840 351626..351805 + 180 WP_001883039.1 DUF645 family protein -
AN947_RS01845 352001..352426 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
AN947_RS01850 352575..352922 + 348 WP_000933409.1 hypothetical protein -
AN947_RS20745 353069..353362 + 294 WP_125460920.1 hypothetical protein -
AN947_RS20750 353718..353813 + 96 WP_001907607.1 DUF645 family protein -
AN947_RS01865 354007..354324 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN947_RS01870 354343..354585 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AN947_RS01875 354827..355336 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
AN947_RS01880 355393..356046 + 654 WP_000226874.1 hypothetical protein -
AN947_RS01885 356356..356574 + 219 WP_001917086.1 DUF3709 domain-containing protein -
AN947_RS01895 356977..357210 + 234 WP_032482776.1 DUF3709 domain-containing protein -
AN947_RS01900 357635..357815 + 181 Protein_344 DUF645 family protein -
AN947_RS01905 358082..358369 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
AN947_RS01910 358380..358697 + 318 WP_001232701.1 HigA family addiction module antidote protein -
AN947_RS20755 358694..358804 + 111 WP_134814058.1 DUF3265 domain-containing protein -
AN947_RS01920 358981..359106 + 126 WP_001944767.1 DUF645 family protein -
AN947_RS20760 359122..359160 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T56914 WP_001180243.1 NZ_CP012666:c354324-354007 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T56914 NZ_CP012666:c354324-354007 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT56914 WP_000557292.1 NZ_CP012666:c354585-354343 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT56914 NZ_CP012666:c354585-354343 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References