58303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 463720..464258 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ87_RS16510 Protein ID WP_000802136.1
Coordinates 463720..464019 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ87_RS16515 Protein ID WP_001107719.1
Coordinates 464016..464258 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ87_RS16450 458925..459107 + 183 WP_000923340.1 DUF645 family protein -
ASZ87_RS16455 459322..459861 + 540 WP_000099372.1 hypothetical protein -
ASZ87_RS16460 459984..460499 + 516 WP_000090011.1 hypothetical protein -
ASZ87_RS16465 460634..461170 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ87_RS16470 461639..461749 + 111 WP_071908335.1 DUF3265 domain-containing protein -
ASZ87_RS16480 461962..462114 + 153 WP_001884520.1 DUF645 family protein -
ASZ87_RS16485 462398..462841 + 444 WP_000803902.1 hypothetical protein -
ASZ87_RS16490 462845..462955 + 111 WP_071908336.1 DUF3265 domain-containing protein -
ASZ87_RS16495 462985..463263 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ASZ87_RS16500 463260..463544 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ87_RS16510 463720..464019 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ87_RS16515 464016..464258 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ASZ87_RS16525 464677..464754 + 78 WP_071908337.1 DUF645 family protein -
ASZ87_RS20990 464758..464784 + 27 Protein_414 hypothetical protein -
ASZ87_RS21065 465370..465513 + 144 WP_001900215.1 hypothetical protein -
ASZ87_RS20560 465607..465786 + 180 Protein_416 DUF645 family protein -
ASZ87_RS16550 466004..466432 + 429 WP_000620002.1 N-acetyltransferase -
ASZ87_RS16560 467020..467502 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
ASZ87_RS16570 468310..468579 + 270 WP_001114075.1 DUF4160 domain-containing protein -
ASZ87_RS16575 468573..469094 + 522 WP_000921692.1 DUF2442 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 435534..596659 161125
inside Integron - - 440614..596283 155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58303 WP_000802136.1 NZ_CP013310:c464019-463720 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58303 NZ_CP013310:c464019-463720 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58303 WP_001107719.1 NZ_CP013310:c464258-464016 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58303 NZ_CP013310:c464258-464016 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References