145841

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 433434..433993 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTF73_RS16190 Protein ID WP_000578476.1
Coordinates 433434..433712 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTF73_RS16195 Protein ID WP_000381183.1
Coordinates 433709..433993 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS16145 428734..429171 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTF73_RS16150 429235..429453 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GTF73_RS16155 429628..430500 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GTF73_RS16160 430650..431249 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GTF73_RS16165 431306..431410 + 105 WP_099607150.1 acetyltransferase -
GTF73_RS16170 431441..431710 + 270 WP_001114075.1 DUF4160 domain-containing protein -
GTF73_RS16175 431704..432225 + 522 WP_000921691.1 DUF2442 domain-containing protein -
GTF73_RS16180 432524..432649 + 126 WP_001905700.1 DUF645 family protein -
GTF73_RS16185 432900..433295 + 396 WP_001000867.1 hypothetical protein -
GTF73_RS16190 433434..433712 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GTF73_RS16195 433709..433993 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTF73_RS16200 434187..434702 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
GTF73_RS16205 434759..434854 + 96 WP_099607151.1 acetyltransferase -
GTF73_RS16210 434886..435299 + 414 WP_000049420.1 VOC family protein -
GTF73_RS16215 435306..435438 - 133 Protein_486 hypothetical protein -
GTF73_RS16220 435854..437031 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805
flank IS/Tn - - 428734..429171 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145841 WP_000578476.1 NZ_CP047298:c433712-433434 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145841 NZ_CP062702:c2564845-2564567 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145841 WP_000381183.1 NZ_CP047298:c433993-433709 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145841 NZ_CP062702:c2565038-2564847 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References