Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 335266..336032 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GPY07_RS15840 Protein ID WP_000982260.1
Coordinates 335535..336032 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GPY07_RS15835 Protein ID WP_000246253.1
Coordinates 335266..335538 (+) Length 91 a.a.

Genomic Context

GPY07_RS15835GPY07_RS15840GPY07_RS15790GPY07_RS15795GPY07_RS15800GPY07_RS15810GPY07_RS19430GPY07_RS15820GPY07_RS15825GPY07_RS15830GPY07_RS15850GPY07_RS15855GPY07_RS15860GPY07_RS15865GPY07_RS15870GPY07_RS15875GPY07_RS15880GPY07_RS15885GPY07_RS15890
Location: 335266..335538 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 335535..336032 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 330494..331411 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 331645..331947 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 331935..332192 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 332394..332927 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 332924..333349 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 333416..333787 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 333928..334215 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 334367..335035 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 336234..336386 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 336708..337163 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 337291..337578 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 337568..337819 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 338033..338446 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 338521..338664 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 338634..339035 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 339035..339727 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 339864..340170 (307 bp)
Type: Others
Protein ID: Protein_310
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY07_RS15790330494..331411-918WP_000186333.1alpha/beta hydrolase-
GPY07_RS15795331645..331947-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY07_RS15800331935..332192-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY07_RS15810332394..332927-534WP_000118351.1GNAT family N-acetyltransferase-
GPY07_RS19430332924..333349-426WP_001882332.1DUF1778 domain-containing protein-
GPY07_RS15820333416..333787-372WP_001164080.1nucleotide pyrophosphohydrolase-
GPY07_RS15825333928..334215-288WP_000426470.1hypothetical protein-
GPY07_RS15830334367..335035-669WP_000043871.1hypothetical protein-
GPY07_RS15835335266..335538+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
GPY07_RS15840335535..336032+498WP_000982260.1GNAT family N-acetyltransferaseToxin
GPY07_RS15850336234..336386-153WP_001884520.1DUF645 family protein-
GPY07_RS15855336708..337163-456WP_001245327.1GNAT family N-acetyltransferase-
GPY07_RS15860337291..337578-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY07_RS15865337568..337819-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY07_RS15870338033..338446-414WP_000049417.1VOC family protein-
GPY07_RS15875338521..338664-144WP_071908341.1DUF3265 domain-containing protein-
GPY07_RS15880338634..339035-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GPY07_RS15885339035..339727-693WP_001047169.1GNAT family N-acetyltransferase-
GPY07_RS15890339864..340170-307Protein_310CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-322056..41902496968
insideIntegron--322432..41223689804
flankIS/Tn--340238..341218980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145061 WP_000982260.1 NZ_CP046841:335535-336032 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145061 NZ_CP062252:c2853960-2852893 [Pseudomonas allokribbensis]
ATGAACCTCGAAAAAATCAAGGGACGCCTCGACTTTCTGCGCGAAGCAGAACGGCTCAAGGACGTCCTCAGAAGCGCCCA
CACCTCCTCCGGTCGCAACGAAAGCACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCGATCTTGTTCGCCGATGACC
TGGCCGGGCTCGACGTGCTGAAAGTCCTGAAAATGTGCGTCATCCACGACCTCGGCGAAGCCATCAACGGTGATATCCCG
GCGGTCAACAAAGCCGACTTCCCCGACAAAGGTGAACAGGAGCGCAACGACTTGCTGCTGCTCACCCGTTCCCTGGACGA
CGCGCTGAGAAACGAAATCCTCGTGCTCTGGGACGACTACGAAAACGCCCGTTCTCCCGAAGCCAAAGCGGTGAAGGCGC
TGGACAAGCTGGAAACACTTTTACAACACACTCAAGGCAAGAATCCGCCAGACTTCGACTATGGCTTCAACCTGGCCTAC
GGCAAGCAATACACCAACGCCGATCCGCTGTTCGAAACTCTTCGAACCCTGATCGACCGGGATACCCGAGAACGCATGAA
TACAAATATCACCCTCCGCAACGAACGCCCCGAAGACATCGACGCCATCGCCCGAATCACCGAGGCCGCGTTCCAGCACG
AAGAACACTCCAGCCACACCGAACAATTCATCGTCAACGCCTTGCGCCGCGCCGGTCAGCTCAGCGTTTCGCTGGTGGCC
GTCGAGAACGACACGGTGGTCGGCCATGTCGCCATTTCACCTGTGACGATTTCCTCCGGCACACAAGACTGGTATGGCCT
GGGCCCGATCTCCGTGTGCCCGACCCGCCAGCAGCAAGGCATCGGCTCGGCGCTGATGAAAGCCTCGCTGGCGGAGTTGC
AGCGCATTGGCGGGGTTGGCTGCGTGGTGCTTGGCGATCCGGGCTACTACGGCCGCTTCGGCTTCAAGGCCCATGCAGGT
CTGGAGTTGCCGGGGATTCCGGCGGAGTACTTTCAGGCGTTGGCGTTTGGCGGGGAATTGCCGGTCGGTGTCGTGAAGTA
TCACGAGGCTTTCGACGCTACCGCGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145061 WP_000246253.1 NZ_CP046841:335266-335538 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145061 NZ_CP062252:c2854603-2854046 [Pseudomonas allokribbensis]
ATGCCCGACACATTGTTGAAGCCCAGTCTGCCCGGCATCGCCCTGCGCCGCTGGCGAGTGCTGCATCGCGTCAAGCAGAG
CCACGCCGCCGAGTTGTTCAAGGTCACCCAGTCGACGATTTCCCGCTGGGAAAGCGGCATGCAGGCAATGGACCCGGAGG
CGCACAGGCAACTCGAGACTTTGCTCGCAGCACGACTCGACAGCGCGGCCGATCAGGCCCTCGCACGACTGGTTACGGAC
AGTGCACGCCCGGTTCACCTGGTCTGCGATCTGACCCATCGCCTGCTGGCCTGCTCCCCGGCCCGCGCCGCGCAGTTCAG
CAGTCCGCTGAGCGATCTGCTGGGGCAATCGCTGTGGCGCTTTGCGACGGCGCAAATCCAGCACAAGGAGTCCTTGCTGG
ATGACGCTGGCTGGCGAGAAGTCCAGGCGCCACCAGCACTGGAATTCGTCACCGGCCACAATGATTCAACCCTTGTCCCC
ATCCGCGAAAGTCTTTGCCGCTGGACGCGGATCGCACTTTCGGACGGCACCGCCGCACGGCTGGTGGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References