145061

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 335266..336032 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GPY07_RS15840 Protein ID WP_000982260.1
Coordinates 335535..336032 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GPY07_RS15835 Protein ID WP_000246253.1
Coordinates 335266..335538 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS15790 330494..331411 - 918 WP_000186333.1 alpha/beta hydrolase -
GPY07_RS15795 331645..331947 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY07_RS15800 331935..332192 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPY07_RS15810 332394..332927 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
GPY07_RS19430 332924..333349 - 426 WP_001882332.1 DUF1778 domain-containing protein -
GPY07_RS15820 333416..333787 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GPY07_RS15825 333928..334215 - 288 WP_000426470.1 hypothetical protein -
GPY07_RS15830 334367..335035 - 669 WP_000043871.1 hypothetical protein -
GPY07_RS15835 335266..335538 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GPY07_RS15840 335535..336032 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GPY07_RS15850 336234..336386 - 153 WP_001884520.1 DUF645 family protein -
GPY07_RS15855 336708..337163 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
GPY07_RS15860 337291..337578 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY07_RS15865 337568..337819 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPY07_RS15870 338033..338446 - 414 WP_000049417.1 VOC family protein -
GPY07_RS15875 338521..338664 - 144 WP_071908341.1 DUF3265 domain-containing protein -
GPY07_RS15880 338634..339035 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GPY07_RS15885 339035..339727 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
GPY07_RS15890 339864..340170 - 307 Protein_310 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804
flank IS/Tn - - 340238..341218 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145061 WP_000982260.1 NZ_CP046841:335535-336032 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145061 NZ_CP062252:c2853960-2852893 [Pseudomonas allokribbensis]
ATGAACCTCGAAAAAATCAAGGGACGCCTCGACTTTCTGCGCGAAGCAGAACGGCTCAAGGACGTCCTCAGAAGCGCCCA
CACCTCCTCCGGTCGCAACGAAAGCACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCGATCTTGTTCGCCGATGACC
TGGCCGGGCTCGACGTGCTGAAAGTCCTGAAAATGTGCGTCATCCACGACCTCGGCGAAGCCATCAACGGTGATATCCCG
GCGGTCAACAAAGCCGACTTCCCCGACAAAGGTGAACAGGAGCGCAACGACTTGCTGCTGCTCACCCGTTCCCTGGACGA
CGCGCTGAGAAACGAAATCCTCGTGCTCTGGGACGACTACGAAAACGCCCGTTCTCCCGAAGCCAAAGCGGTGAAGGCGC
TGGACAAGCTGGAAACACTTTTACAACACACTCAAGGCAAGAATCCGCCAGACTTCGACTATGGCTTCAACCTGGCCTAC
GGCAAGCAATACACCAACGCCGATCCGCTGTTCGAAACTCTTCGAACCCTGATCGACCGGGATACCCGAGAACGCATGAA
TACAAATATCACCCTCCGCAACGAACGCCCCGAAGACATCGACGCCATCGCCCGAATCACCGAGGCCGCGTTCCAGCACG
AAGAACACTCCAGCCACACCGAACAATTCATCGTCAACGCCTTGCGCCGCGCCGGTCAGCTCAGCGTTTCGCTGGTGGCC
GTCGAGAACGACACGGTGGTCGGCCATGTCGCCATTTCACCTGTGACGATTTCCTCCGGCACACAAGACTGGTATGGCCT
GGGCCCGATCTCCGTGTGCCCGACCCGCCAGCAGCAAGGCATCGGCTCGGCGCTGATGAAAGCCTCGCTGGCGGAGTTGC
AGCGCATTGGCGGGGTTGGCTGCGTGGTGCTTGGCGATCCGGGCTACTACGGCCGCTTCGGCTTCAAGGCCCATGCAGGT
CTGGAGTTGCCGGGGATTCCGGCGGAGTACTTTCAGGCGTTGGCGTTTGGCGGGGAATTGCCGGTCGGTGTCGTGAAGTA
TCACGAGGCTTTCGACGCTACCGCGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145061 WP_000246253.1 NZ_CP046841:335266-335538 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145061 NZ_CP062252:c2854603-2854046 [Pseudomonas allokribbensis]
ATGCCCGACACATTGTTGAAGCCCAGTCTGCCCGGCATCGCCCTGCGCCGCTGGCGAGTGCTGCATCGCGTCAAGCAGAG
CCACGCCGCCGAGTTGTTCAAGGTCACCCAGTCGACGATTTCCCGCTGGGAAAGCGGCATGCAGGCAATGGACCCGGAGG
CGCACAGGCAACTCGAGACTTTGCTCGCAGCACGACTCGACAGCGCGGCCGATCAGGCCCTCGCACGACTGGTTACGGAC
AGTGCACGCCCGGTTCACCTGGTCTGCGATCTGACCCATCGCCTGCTGGCCTGCTCCCCGGCCCGCGCCGCGCAGTTCAG
CAGTCCGCTGAGCGATCTGCTGGGGCAATCGCTGTGGCGCTTTGCGACGGCGCAAATCCAGCACAAGGAGTCCTTGCTGG
ATGACGCTGGCTGGCGAGAAGTCCAGGCGCCACCAGCACTGGAATTCGTCACCGGCCACAATGATTCAACCCTTGTCCCC
ATCCGCGAAAGTCTTTGCCGCTGGACGCGGATCGCACTTTCGGACGGCACCGCCGCACGGCTGGTGGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References