48154

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 389078..389711 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag IR04_RS01940 Protein ID WP_000843587.1
Coordinates 389078..389410 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IR04_RS01945 Protein ID WP_000071008.1
Coordinates 389397..389711 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR04_RS20315 384519..384722 + 204 WP_001911745.1 hypothetical protein -
IR04_RS20015 385003..385176 + 174 WP_001882305.1 DUF3709 domain-containing protein -
IR04_RS01915 385536..385805 + 270 WP_001198131.1 hypothetical protein -
IR04_RS19360 386123..386294 + 172 Protein_391 DUF645 family protein -
IR04_RS01920 386503..386889 + 387 WP_000703163.1 VOC family protein -
IR04_RS01925 387091..387333 + 243 WP_000107461.1 hypothetical protein -
IR04_RS01930 387504..387881 + 378 WP_000411109.1 hypothetical protein -
IR04_RS20415 387938..388052 + 115 Protein_395 acetyltransferase -
IR04_RS19365 388001..388282 + 282 WP_001894453.1 DUF1289 domain-containing protein -
IR04_RS19380 388448..388561 + 114 WP_001889158.1 hypothetical protein -
IR04_RS19385 388510..388737 + 228 WP_073426587.1 DUF1289 domain-containing protein -
IR04_RS01940 389078..389410 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IR04_RS01945 389397..389711 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
IR04_RS01950 389848..390282 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
IR04_RS20250 390450..390605 + 156 WP_000751734.1 hypothetical protein -
IR04_RS01960 390730..391710 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
IR04_RS01965 391778..392050 + 273 Protein_404 CatB-related O-acetyltransferase -
IR04_RS01970 392221..392913 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
IR04_RS01975 392913..393314 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
IR04_RS20025 393284..393427 + 144 WP_071908341.1 DUF3265 domain-containing protein -
IR04_RS01980 393502..393915 + 414 WP_000049417.1 VOC family protein -
IR04_RS01985 394129..394380 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IR04_RS01990 394370..394657 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..409892 105192
inside Integron - - 309780..409516 99736
flank IS/Tn - - 390730..391710 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T48154 WP_000843587.1 NZ_CP009041:389078-389410 [Vibrio cholerae O1 biovar El Tor]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T48154 NZ_CP009041:389078-389410 [Vibrio cholerae O1 biovar El Tor]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT48154 WP_000071008.1 NZ_CP009041:389397-389711 [Vibrio cholerae O1 biovar El Tor]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT48154 NZ_CP009041:389397-389711 [Vibrio cholerae O1 biovar El Tor]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References