45813

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 395375..395903 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag N900_RS16030 Protein ID WP_000221354.1
Coordinates 395616..395903 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag N900_RS16025 Protein ID WP_001250179.1
Coordinates 395375..395626 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N900_RS15985 390643..390957 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
N900_RS15990 391094..391528 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
N900_RS20190 391696..391851 + 156 WP_000751734.1 hypothetical protein -
N900_RS16000 391976..392956 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
N900_RS16005 393024..393296 + 273 Protein_403 CatB-related O-acetyltransferase -
N900_RS16010 393467..394159 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
N900_RS16015 394159..394560 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
N900_RS20050 394530..394673 + 144 WP_071908341.1 DUF3265 domain-containing protein -
N900_RS16020 394748..395161 + 414 WP_000049417.1 VOC family protein -
N900_RS16025 395375..395626 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N900_RS16030 395616..395903 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N900_RS16035 396031..396486 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
N900_RS16040 396808..396960 + 153 WP_001884520.1 DUF645 family protein -
N900_RS16045 397162..397659 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
N900_RS16050 397656..397928 - 273 WP_000246253.1 DUF1778 domain-containing protein -
N900_RS16055 398159..398827 + 669 WP_000043871.1 hypothetical protein -
N900_RS16060 398979..399266 + 288 WP_000426470.1 hypothetical protein -
N900_RS16065 399407..399778 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
N900_RS16070 399845..400270 + 426 WP_001882332.1 DUF1778 domain-containing protein -
N900_RS16075 400267..400800 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..411088 106443
inside Integron - - 309725..410760 101035
flank IS/Tn - - 391976..392956 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T45813 WP_000221354.1 NZ_CP006948:395616-395903 [Vibrio cholerae O1 str. KW3]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T45813 NZ_CP006948:395616-395903 [Vibrio cholerae O1 str. KW3]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT45813 WP_001250179.1 NZ_CP006948:395375-395626 [Vibrio cholerae O1 str. KW3]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT45813 NZ_CP006948:395375-395626 [Vibrio cholerae O1 str. KW3]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References