Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 395375..395903 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag N900_RS16030 Protein ID WP_000221354.1
Coordinates 395616..395903 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag N900_RS16025 Protein ID WP_001250179.1
Coordinates 395375..395626 (+) Length 84 a.a.

Genomic Context

N900_RS15985N900_RS15990N900_RS20190N900_RS16005N900_RS16010N900_RS16015N900_RS20050N900_RS16020N900_RS16025N900_RS16030N900_RS16035N900_RS16040N900_RS16055N900_RS16060N900_RS16065N900_RS16070N900_RS16075N900_RS16000N900_RS16045N900_RS16050
Location: 390643..390957 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 391094..391528 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 391696..391851 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 393024..393296 (273 bp)
Type: Others
Protein ID: Protein_403
Location: 393467..394159 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 394159..394560 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 394530..394673 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 394748..395161 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 395375..395626 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 395616..395903 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 396031..396486 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 396808..396960 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 398159..398827 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 398979..399266 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 399407..399778 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 399845..400270 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 400267..400800 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 391976..392956 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 397162..397659 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 397656..397928 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N900_RS15985390643..390957+315WP_000071008.1DNA-binding transcriptional regulator-
N900_RS15990391094..391528+435WP_000256036.1GNAT family N-acetyltransferase-
N900_RS20190391696..391851+156WP_000751734.1hypothetical protein-
N900_RS16000391976..392956-981WP_000019370.1IS5-like element ISVch5 family transposase-
N900_RS16005393024..393296+273Protein_403CatB-related O-acetyltransferase-
N900_RS16010393467..394159+693WP_001047169.1GNAT family N-acetyltransferase-
N900_RS16015394159..394560+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
N900_RS20050394530..394673+144WP_071908341.1DUF3265 domain-containing protein-
N900_RS16020394748..395161+414WP_000049417.1VOC family protein-
N900_RS16025395375..395626+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
N900_RS16030395616..395903+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N900_RS16035396031..396486+456WP_001245327.1GNAT family N-acetyltransferase-
N900_RS16040396808..396960+153WP_001884520.1DUF645 family protein-
N900_RS16045397162..397659-498WP_000982260.1GNAT family N-acetyltransferase-
N900_RS16050397656..397928-273WP_000246253.1DUF1778 domain-containing protein-
N900_RS16055398159..398827+669WP_000043871.1hypothetical protein-
N900_RS16060398979..399266+288WP_000426470.1hypothetical protein-
N900_RS16065399407..399778+372WP_001164080.1nucleotide pyrophosphohydrolase-
N900_RS16070399845..400270+426WP_001882332.1DUF1778 domain-containing protein-
N900_RS16075400267..400800+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..411088106443
insideIntegron--309725..410760101035
flankIS/Tn--391976..392956980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T45813 WP_000221354.1 NZ_CP006948:395616-395903 [Vibrio cholerae O1 str. KW3]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T45813 NZ_CP006948:395616-395903 [Vibrio cholerae O1 str. KW3]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT45813 WP_001250179.1 NZ_CP006948:395375-395626 [Vibrio cholerae O1 str. KW3]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT45813 NZ_CP006948:395375-395626 [Vibrio cholerae O1 str. KW3]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References