Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 119596..120211 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag ASZ83_RS14600 Protein ID WP_001162670.1
Coordinates 119596..119883 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ83_RS14605 Protein ID WP_001232701.1
Coordinates 119894..120211 (+) Length 106 a.a.

Genomic Context

ASZ83_RS14555ASZ83_RS14560ASZ83_RS14565ASZ83_RS14570ASZ83_RS20010ASZ83_RS14585ASZ83_RS14595ASZ83_RS14600ASZ83_RS14605ASZ83_RS20435ASZ83_RS14615ASZ83_RS14620ASZ83_RS14625ASZ83_RS20030ASZ83_RS20035ASZ83_RS14630ASZ83_RS14635ASZ83_RS14640ASZ83_RS14645ASZ83_RS14650ASZ83_RS14655
Location: 115088..115345 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 115333..115635 (303 bp)
Type: Others
Protein ID: WP_000229318.1
Location: 115924..116148 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 116592..116711 (120 bp)
Type: Others
Protein ID: WP_071919600.1
Location: 116715..116768 (54 bp)
Type: Others
Protein ID: Protein_123
Location: 117370..118374 (1005 bp)
Type: Others
Protein ID: WP_000964931.1
Location: 119149..119329 (181 bp)
Type: Others
Protein ID: Protein_125
Location: 119596..119883 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 119894..120211 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 120208..120318 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 120364..120903 (540 bp)
Type: Others
Protein ID: WP_000099372.1
Location: 121048..121482 (435 bp)
Type: Others
Protein ID: WP_000453680.1
Location: 121709..121987 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 122239..122445 (207 bp)
Type: Others
Protein ID: Protein_132
Location: 122645..122746 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 122736..123122 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 123317..123568 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 123541..123690 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 123804..124247 (444 bp)
Type: Others
Protein ID: WP_000803902.1
Location: 124251..124361 (111 bp)
Type: Others
Protein ID: WP_071908336.1
Location: 124574..124726 (153 bp)
Type: Others
Protein ID: WP_001884520.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS14555115088..115345+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ83_RS14560115333..115635+303WP_000229318.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ83_RS14565115924..116148+225WP_001894423.1DUF3709 domain-containing protein-
ASZ83_RS14570116592..116711+120WP_071919600.1DUF645 family protein-
ASZ83_RS20010116715..116768+54Protein_123DUF645 family protein-
ASZ83_RS14585117370..118374+1005WP_000964931.1LD-carboxypeptidase-
ASZ83_RS14595119149..119329+181Protein_125DUF645 family protein-
ASZ83_RS14600119596..119883+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ83_RS14605119894..120211+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
ASZ83_RS20435120208..120318+111WP_134814058.1DUF3265 domain-containing protein-
ASZ83_RS14615120364..120903+540WP_000099372.1hypothetical protein-
ASZ83_RS14620121048..121482+435WP_000453680.1GNAT family N-acetyltransferase-
ASZ83_RS14625121709..121987+279WP_001921601.1DUF3709 domain-containing protein-
ASZ83_RS20030122239..122445+207Protein_132DUF3709 domain-containing protein-
ASZ83_RS20035122645..122746+102WP_001921603.1hypothetical protein-
ASZ83_RS14630122736..123122+387WP_000703163.1VOC family protein-
ASZ83_RS14635123317..123568+252WP_001890111.1TIGR03643 family protein-
ASZ83_RS14640123541..123690+150WP_071908333.1DUF3265 domain-containing protein-
ASZ83_RS14645123804..124247+444WP_000803902.1hypothetical protein-
ASZ83_RS14650124251..124361+111WP_071908336.1DUF3265 domain-containing protein-
ASZ83_RS14655124574..124726+153WP_001884520.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T58376 WP_001162670.1 NZ_CP013316:119596-119883 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T58376 NZ_CP013316:119596-119883 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT58376 WP_001232701.1 NZ_CP013316:119894-120211 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT58376 NZ_CP013316:119894-120211 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References