58317

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 580896..581424 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag ASZ87_RS17680 Protein ID WP_000221354.1
Coordinates 581137..581424 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag ASZ87_RS17675 Protein ID WP_001250179.1
Coordinates 580896..581147 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ87_RS17625 576164..576478 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
ASZ87_RS17630 576615..577049 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
ASZ87_RS20915 577217..577372 + 156 WP_000751734.1 hypothetical protein -
ASZ87_RS17645 577497..578477 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
ASZ87_RS17650 578545..578851 + 307 Protein_610 CatB-related O-acetyltransferase -
ASZ87_RS17655 578988..579680 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
ASZ87_RS17660 579680..580081 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
ASZ87_RS20820 580051..580194 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ87_RS17670 580269..580682 + 414 WP_000049417.1 VOC family protein -
ASZ87_RS17675 580896..581147 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ87_RS17680 581137..581424 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ87_RS17685 581552..582007 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ87_RS17695 582329..582481 + 153 WP_001884520.1 DUF645 family protein -
ASZ87_RS17700 582683..583180 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ87_RS17705 583177..583449 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ87_RS17710 583680..584348 + 669 WP_000043871.1 hypothetical protein -
ASZ87_RS17715 584500..584787 + 288 WP_000426470.1 hypothetical protein -
ASZ87_RS17720 584928..585299 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ87_RS17725 585366..585791 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ASZ87_RS17730 585788..586321 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 435534..596659 161125
inside Integron - - 440614..596283 155669
flank IS/Tn - - 577497..578477 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T58317 WP_000221354.1 NZ_CP013310:581137-581424 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T58317 NZ_CP013310:581137-581424 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT58317 WP_001250179.1 NZ_CP013310:580896-581147 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT58317 NZ_CP013310:580896-581147 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References