294380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 440399..440937 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag DG176_RS16640 Protein ID WP_000802136.1
Coordinates 440638..440937 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag DG176_RS16635 Protein ID WP_001107719.1
Coordinates 440399..440641 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG176_RS16580 435815..435955 - 141 WP_001883049.1 DUF3265 domain-containing protein -
DG176_RS16585 435921..436856 - 936 WP_000051985.1 restriction endonuclease -
DG176_RS16590 437137..437736 - 600 WP_000429495.1 hypothetical protein -
DG176_RS16600 437891..438157 - 267 WP_000937852.1 hypothetical protein -
DG176_RS16610 438371..439054 - 684 WP_000877436.1 hypothetical protein -
DG176_RS16620 439478..439570 - 93 WP_014164112.1 DUF3265 domain-containing protein -
DG176_RS16625 439592..440170 - 579 WP_000110120.1 hypothetical protein -
DG176_RS16635 440399..440641 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DG176_RS16640 440638..440937 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DG176_RS16645 441065..441460 - 396 WP_000870857.1 DUF3465 domain-containing protein -
DG176_RS16650 441674..441853 - 180 WP_001883058.1 DUF645 family protein -
DG176_RS16665 442431..442541 - 111 WP_079857360.1 DUF3265 domain-containing protein -
DG176_RS16670 442551..443249 - 699 WP_001890502.1 hypothetical protein -
DG176_RS16675 443372..443998 - 627 WP_000365424.1 LysE family translocator -
DG176_RS16680 444040..444132 - 93 WP_014378730.1 DUF3265 domain-containing protein -
DG176_RS16685 444147..444620 - 474 WP_001161076.1 GrpB family protein -
DG176_RS16690 444820..445002 - 183 WP_000923182.1 DUF645 family protein -
DG176_RS19830 445063..445191 - 129 WP_071908338.1 general secretion pathway protein GspI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 379325..476297 96972
inside Integron catB9 - 379701..469509 89808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T294380 WP_000802136.1 NZ_LT992489:440638-440937 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T294380 NZ_LT992489:440638-440937 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT294380 WP_001107719.1 NZ_LT992489:440399-440641 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT294380 NZ_LT992489:440399-440641 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References