Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 440399..440937 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag DG176_RS16640 Protein ID WP_000802136.1
Coordinates 440638..440937 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag DG176_RS16635 Protein ID WP_001107719.1
Coordinates 440399..440641 (+) Length 81 a.a.

Genomic Context

DG176_RS16635DG176_RS16640DG176_RS16580DG176_RS16585DG176_RS16590DG176_RS16600DG176_RS16610DG176_RS16620DG176_RS16625DG176_RS16645DG176_RS16650DG176_RS16665DG176_RS16670DG176_RS16675DG176_RS16680DG176_RS16685DG176_RS16690DG176_RS19830
Location: 440399..440641 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
Location: 440638..440937 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 435815..435955 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 435921..436856 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 437137..437736 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 437891..438157 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 438371..439054 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 439478..439570 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 439592..440170 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 441065..441460 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 441674..441853 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 442431..442541 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 442551..443249 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 443372..443998 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 444040..444132 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 444147..444620 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 444820..445002 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 445063..445191 (129 bp)
Type: Others
Protein ID: WP_071908338.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG176_RS16580435815..435955-141WP_001883049.1DUF3265 domain-containing protein-
DG176_RS16585435921..436856-936WP_000051985.1restriction endonuclease-
DG176_RS16590437137..437736-600WP_000429495.1hypothetical protein-
DG176_RS16600437891..438157-267WP_000937852.1hypothetical protein-
DG176_RS16610438371..439054-684WP_000877436.1hypothetical protein-
DG176_RS16620439478..439570-93WP_014164112.1DUF3265 domain-containing protein-
DG176_RS16625439592..440170-579WP_000110120.1hypothetical protein-
DG176_RS16635440399..440641+243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
DG176_RS16640440638..440937+300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG176_RS16645441065..441460-396WP_000870857.1DUF3465 domain-containing protein-
DG176_RS16650441674..441853-180WP_001883058.1DUF645 family protein-
DG176_RS16665442431..442541-111WP_079857360.1DUF3265 domain-containing protein-
DG176_RS16670442551..443249-699WP_001890502.1hypothetical protein-
DG176_RS16675443372..443998-627WP_000365424.1LysE family translocator-
DG176_RS16680444040..444132-93WP_014378730.1DUF3265 domain-containing protein-
DG176_RS16685444147..444620-474WP_001161076.1GrpB family protein-
DG176_RS16690444820..445002-183WP_000923182.1DUF645 family protein-
DG176_RS19830445063..445191-129WP_071908338.1general secretion pathway protein GspI-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-379325..47629796972
insideIntegroncatB9-379701..46950989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T294380 WP_000802136.1 NZ_LT992489:440638-440937 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T294380 NZ_LT992489:440638-440937 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT294380 WP_001107719.1 NZ_LT992489:440399-440641 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT294380 NZ_LT992489:440399-440641 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References