125037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 902433..903199 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag FDZ90_RS18675 Protein ID WP_000982260.1
Coordinates 902433..902930 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag FDZ90_RS18680 Protein ID WP_000246253.1
Coordinates 902927..903199 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ90_RS18630 897875..898579 + 705 WP_000087610.1 HNH endonuclease -
FDZ90_RS18635 898737..899075 + 339 WP_000713853.1 hypothetical protein -
FDZ90_RS18640 899229..899546 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
FDZ90_RS18645 899565..899807 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FDZ90_RS18650 900051..900437 + 387 WP_001015867.1 NUDIX hydrolase -
FDZ90_RS18655 900494..900607 + 114 WP_001900214.1 hypothetical protein -
FDZ90_RS18660 900556..900837 + 282 WP_001894429.1 DUF1289 domain-containing protein -
FDZ90_RS18665 901095..901631 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
FDZ90_RS18670 901768..902283 + 516 WP_001201509.1 lipocalin family protein -
FDZ90_RS18675 902433..902930 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
FDZ90_RS18680 902927..903199 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
FDZ90_RS18685 903592..903717 + 126 WP_001900195.1 DUF645 family protein -
FDZ90_RS18690 903733..903771 + 39 WP_106019118.1 hypothetical protein -
FDZ90_RS18695 903966..904412 + 447 WP_000006157.1 hypothetical protein -
FDZ90_RS18700 904560..904829 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
FDZ90_RS18705 904822..905100 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
FDZ90_RS18710 905386..905664 + 279 WP_001921601.1 DUF3709 domain-containing protein -
FDZ90_RS18715 905916..906122 + 207 Protein_796 DUF3709 domain-containing protein -
FDZ90_RS18720 906322..906423 + 102 WP_001921603.1 hypothetical protein -
FDZ90_RS18725 906413..906799 + 387 WP_000703163.1 VOC family protein -
FDZ90_RS18730 906994..907245 + 252 WP_001890111.1 TIGR03643 family protein -
FDZ90_RS18735 907218..907367 + 150 WP_071908333.1 DUF3265 domain-containing protein -
FDZ90_RS18740 907459..907701 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 882589..977840 95251
inside Integron catB9 - 887669..977464 89795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T125037 WP_000982260.1 NZ_CP040173:c902930-902433 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T125037 NZ_CP040173:c902930-902433 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT125037 WP_000246253.1 NZ_CP040173:c903199-902927 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT125037 NZ_CP040173:c903199-902927 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References