87025

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 413130..413763 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag CSW01_RS16660 Protein ID WP_000843587.1
Coordinates 413130..413462 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CSW01_RS16665 Protein ID WP_000071008.1
Coordinates 413449..413763 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS19990 408571..408774 + 204 WP_001911745.1 hypothetical protein -
CSW01_RS19845 409055..409228 + 174 WP_001882305.1 DUF3709 domain-containing protein -
CSW01_RS16590 409588..409857 + 270 WP_001198131.1 hypothetical protein -
CSW01_RS16605 410175..410346 + 172 Protein_430 DUF645 family protein -
CSW01_RS16610 410555..410941 + 387 WP_000703163.1 VOC family protein -
CSW01_RS16615 411143..411385 + 243 WP_000107461.1 hypothetical protein -
CSW01_RS16620 411556..411933 + 378 WP_000411109.1 hypothetical protein -
CSW01_RS19995 411990..412104 + 115 Protein_434 acetyltransferase -
CSW01_RS16625 412053..412334 + 282 WP_001894453.1 DUF1289 domain-containing protein -
CSW01_RS16640 412500..412613 + 114 WP_001889158.1 hypothetical protein -
CSW01_RS16645 412562..412789 + 228 WP_001894457.1 DUF1289 domain-containing protein -
CSW01_RS16660 413130..413462 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSW01_RS16665 413449..413763 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
CSW01_RS16675 413900..414334 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
CSW01_RS19850 414502..414657 + 156 WP_000751734.1 hypothetical protein -
CSW01_RS16680 414782..415762 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
CSW01_RS16685 415830..416136 + 307 Protein_443 CatB-related O-acetyltransferase -
CSW01_RS16690 416273..416965 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
CSW01_RS16695 416965..417366 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
CSW01_RS16700 417336..417479 + 144 WP_071908341.1 DUF3265 domain-containing protein -
CSW01_RS16705 417554..417967 + 414 WP_000049417.1 VOC family protein -
CSW01_RS16710 418181..418432 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CSW01_RS16715 418422..418709 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262
flank IS/Tn - - 414782..415762 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T87025 WP_000843587.1 NZ_CP024163:413130-413462 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T87025 NZ_CP024163:413130-413462 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT87025 WP_000071008.1 NZ_CP024163:413449-413763 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT87025 NZ_CP024163:413449-413763 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References