Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 388065..388702 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GTF72_RS15750 Protein ID WP_000869997.1
Coordinates 388343..388702 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag GTF72_RS15745 Protein ID WP_000086649.1
Coordinates 388065..388346 (+) Length 94 a.a.

Genomic Context

GTF72_RS15710GTF72_RS15715GTF72_RS15720GTF72_RS15725GTF72_RS15730GTF72_RS15735GTF72_RS15740GTF72_RS15745GTF72_RS15750GTF72_RS15755GTF72_RS15760GTF72_RS15765GTF72_RS15770GTF72_RS15780GTF72_RS15785GTF72_RS15790GTF72_RS15795GTF72_RS15775
Location: 383187..383546 (360 bp)
Type: Others
Protein ID: WP_001071514.1
Location: 383729..384052 (324 bp)
Type: Others
Protein ID: WP_001889156.1
Location: 384333..384869 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 385630..385812 (183 bp)
Type: Others
Protein ID: WP_000947517.1
Location: 385931..386716 (786 bp)
Type: Others
Protein ID: WP_001176447.1
Location: 386818..387180 (363 bp)
Type: Others
Protein ID: WP_170831679.1
Location: 387426..387851 (426 bp)
Type: Others
Protein ID: WP_000735184.1
Location: 388065..388346 (282 bp)
Type: Antitoxin
Protein ID: WP_000086649.1
Location: 388343..388702 (360 bp)
Type: Toxin
Protein ID: WP_000869997.1
Location: 388807..389130 (324 bp)
Type: Others
Protein ID: WP_001999495.1
Location: 389416..389811 (396 bp)
Type: Others
Protein ID: WP_000870868.1
Location: 389878..389992 (115 bp)
Type: Others
Protein ID: Protein_401
Location: 390001..390222 (222 bp)
Type: Others
Protein ID: WP_043987927.1
Location: 390586..391011 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 391337..391570 (234 bp)
Type: Others
Protein ID: WP_001999499.1
Location: 391759..392154 (396 bp)
Type: Others
Protein ID: WP_001889207.1
Location: 392373..392762 (390 bp)
Type: Others
Protein ID: WP_000491261.1
Location: 390198..390356 (159 bp)
Type: Others
Protein ID: WP_001909351.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS15710383187..383546+360WP_001071514.1VOC family protein-
GTF72_RS15715383729..384052+324WP_001889156.1DUF3709 domain-containing protein-
GTF72_RS15720384333..384869+537WP_000469482.1GNAT family N-acetyltransferase-
GTF72_RS15725385630..385812+183WP_000947517.1DUF645 family protein-
GTF72_RS15730385931..386716+786WP_001176447.1hypothetical protein-
GTF72_RS15735386818..387180+363WP_170831679.1DUF4144 domain-containing protein-
GTF72_RS15740387426..387851+426WP_000735184.1hypothetical protein-
GTF72_RS15745388065..388346+282WP_000086649.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GTF72_RS15750388343..388702+360WP_000869997.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF72_RS15755388807..389130+324WP_001999495.1DUF3709 domain-containing protein-
GTF72_RS15760389416..389811+396WP_000870868.1DUF3465 domain-containing protein-
GTF72_RS15765389878..389992+115Protein_401acetyltransferase-
GTF72_RS15770390001..390222+222WP_043987927.1DUF1289 domain-containing protein-
GTF72_RS15775390198..390356-159WP_001909351.1DUF1196 family protein-
GTF72_RS15780390586..391011+426WP_000415748.1hypothetical protein-
GTF72_RS15785391337..391570+234WP_001999499.1DUF3709 domain-containing protein-
GTF72_RS15790391759..392154+396WP_001889207.1DUF4144 domain-containing protein-
GTF72_RS15795392373..392762+390WP_000491261.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13608.84 Da        Isoelectric Point: 8.1459

>T145811 WP_000869997.1 NZ_CP047296:388343-388702 [Vibrio cholerae C6706]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTLRQEQTVNPPHNKRLKRDCQRVAFPVPLSRGGCSCCV

Download         Length: 360 bp

>T145811 NZ_CP062700:2280502-2280605 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT145811 WP_000086649.1 NZ_CP047296:388065-388346 [Vibrio cholerae C6706]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT145811 NZ_CP062700:c2280643-2280372 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0K9UIW4

References