145811

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 388065..388702 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GTF72_RS15750 Protein ID WP_000869997.1
Coordinates 388343..388702 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag GTF72_RS15745 Protein ID WP_000086649.1
Coordinates 388065..388346 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF72_RS15710 383187..383546 + 360 WP_001071514.1 VOC family protein -
GTF72_RS15715 383729..384052 + 324 WP_001889156.1 DUF3709 domain-containing protein -
GTF72_RS15720 384333..384869 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF72_RS15725 385630..385812 + 183 WP_000947517.1 DUF645 family protein -
GTF72_RS15730 385931..386716 + 786 WP_001176447.1 hypothetical protein -
GTF72_RS15735 386818..387180 + 363 WP_170831679.1 DUF4144 domain-containing protein -
GTF72_RS15740 387426..387851 + 426 WP_000735184.1 hypothetical protein -
GTF72_RS15745 388065..388346 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF72_RS15750 388343..388702 + 360 WP_000869997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF72_RS15755 388807..389130 + 324 WP_001999495.1 DUF3709 domain-containing protein -
GTF72_RS15760 389416..389811 + 396 WP_000870868.1 DUF3465 domain-containing protein -
GTF72_RS15765 389878..389992 + 115 Protein_401 acetyltransferase -
GTF72_RS15770 390001..390222 + 222 WP_043987927.1 DUF1289 domain-containing protein -
GTF72_RS15775 390198..390356 - 159 WP_001909351.1 DUF1196 family protein -
GTF72_RS15780 390586..391011 + 426 WP_000415748.1 hypothetical protein -
GTF72_RS15785 391337..391570 + 234 WP_001999499.1 DUF3709 domain-containing protein -
GTF72_RS15790 391759..392154 + 396 WP_001889207.1 DUF4144 domain-containing protein -
GTF72_RS15795 392373..392762 + 390 WP_000491261.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306905..436165 129260
inside Integron - - 311985..435789 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13608.84 Da        Isoelectric Point: 8.1459

>T145811 WP_000869997.1 NZ_CP047296:388343-388702 [Vibrio cholerae C6706]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTLRQEQTVNPPHNKRLKRDCQRVAFPVPLSRGGCSCCV

Download         Length: 360 bp

>T145811 NZ_CP062700:2280502-2280605 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT145811 WP_000086649.1 NZ_CP047296:388065-388346 [Vibrio cholerae C6706]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT145811 NZ_CP062700:c2280643-2280372 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References