104253

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 367660..368238 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag N16961_RS15980 Protein ID WP_001180243.1
Coordinates 367660..367977 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag N16961_RS15985 Protein ID WP_000557292.1
Coordinates 367996..368238 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N16961_RS15930 362851..363246 + 396 WP_000046952.1 hypothetical protein -
N16961_RS15935 363549..363730 + 182 Protein_351 DUF645 family protein -
N16961_RS15940 363907..364302 + 396 WP_000046953.1 hypothetical protein -
N16961_RS15945 364446..364982 + 537 WP_000644491.1 nucleotidyltransferase family protein -
N16961_RS15950 365279..365458 + 180 WP_001883039.1 DUF645 family protein -
N16961_RS15955 365654..366079 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
N16961_RS15960 366228..366575 + 348 WP_000933409.1 hypothetical protein -
N16961_RS19620 366722..367015 + 294 WP_125460920.1 hypothetical protein -
N16961_RS19920 367371..367466 + 96 WP_001907607.1 DUF645 family protein -
N16961_RS15980 367660..367977 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N16961_RS15985 367996..368238 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N16961_RS15990 368480..368989 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
N16961_RS15995 369046..369699 + 654 WP_000226874.1 hypothetical protein -
N16961_RS16000 370009..370227 + 219 WP_001917086.1 DUF3709 domain-containing protein -
N16961_RS16005 370630..370863 + 234 WP_032482776.1 DUF3709 domain-containing protein -
N16961_RS16010 371288..371468 + 181 Protein_365 DUF645 family protein -
N16961_RS16020 371735..372022 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
N16961_RS16025 372033..372350 + 318 WP_001232701.1 HigA family addiction module antidote protein -
N16961_RS19925 372347..372457 + 111 WP_134814058.1 DUF3265 domain-containing protein -
N16961_RS19835 372634..372759 + 126 WP_001944767.1 DUF645 family protein -
N16961_RS19840 372775..372813 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306977..438073 131096
inside Integron - - 312057..437697 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T104253 WP_001180243.1 NZ_CP028828:c367977-367660 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T104253 NZ_CP028828:c367977-367660 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT104253 WP_000557292.1 NZ_CP028828:c368238-367996 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT104253 NZ_CP028828:c368238-367996 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References