Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 367660..368238 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag N16961_RS15980 Protein ID WP_001180243.1
Coordinates 367660..367977 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag N16961_RS15985 Protein ID WP_000557292.1
Coordinates 367996..368238 (-) Length 81 a.a.

Genomic Context

N16961_RS15930N16961_RS15935N16961_RS15940N16961_RS15945N16961_RS15950N16961_RS15955N16961_RS15960N16961_RS19620N16961_RS19920N16961_RS15990N16961_RS15995N16961_RS16000N16961_RS16005N16961_RS16010N16961_RS16020N16961_RS16025N16961_RS19925N16961_RS19835N16961_RS19840N16961_RS15980N16961_RS15985
Location: 362851..363246 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 363549..363730 (182 bp)
Type: Others
Protein ID: Protein_351
Location: 363907..364302 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 364446..364982 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 365279..365458 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 365654..366079 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 366228..366575 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 366722..367015 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 367371..367466 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 368480..368989 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 369046..369699 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 370009..370227 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 370630..370863 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 371288..371468 (181 bp)
Type: Others
Protein ID: Protein_365
Location: 371735..372022 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 372033..372350 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 372347..372457 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 372634..372759 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 372775..372813 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 367660..367977 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 367996..368238 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS15930362851..363246+396WP_000046952.1hypothetical protein-
N16961_RS15935363549..363730+182Protein_351DUF645 family protein-
N16961_RS15940363907..364302+396WP_000046953.1hypothetical protein-
N16961_RS15945364446..364982+537WP_000644491.1nucleotidyltransferase family protein-
N16961_RS15950365279..365458+180WP_001883039.1DUF645 family protein-
N16961_RS15955365654..366079+426WP_000403014.1GNAT family N-acetyltransferase-
N16961_RS15960366228..366575+348WP_000933409.1hypothetical protein-
N16961_RS19620366722..367015+294WP_125460920.1hypothetical protein-
N16961_RS19920367371..367466+96WP_001907607.1DUF645 family protein-
N16961_RS15980367660..367977-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N16961_RS15985367996..368238-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
N16961_RS15990368480..368989+510WP_000405987.1GNAT family N-acetyltransferase-
N16961_RS15995369046..369699+654WP_000226874.1hypothetical protein-
N16961_RS16000370009..370227+219WP_001917086.1DUF3709 domain-containing protein-
N16961_RS16005370630..370863+234WP_032482776.1DUF3709 domain-containing protein-
N16961_RS16010371288..371468+181Protein_365DUF645 family protein-
N16961_RS16020371735..372022+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
N16961_RS16025372033..372350+318WP_001232701.1HigA family addiction module antidote protein-
N16961_RS19925372347..372457+111WP_134814058.1DUF3265 domain-containing protein-
N16961_RS19835372634..372759+126WP_001944767.1DUF645 family protein-
N16961_RS19840372775..372813+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T104253 WP_001180243.1 NZ_CP028828:c367977-367660 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T104253 NZ_CP028828:c367977-367660 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT104253 WP_000557292.1 NZ_CP028828:c368238-367996 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT104253 NZ_CP028828:c368238-367996 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References