Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 431454..432238 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag J9265_RS16125 Protein ID WP_001114075.1
Coordinates 431454..431723 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag J9265_RS16130 Protein ID WP_000921691.1
Coordinates 431717..432238 (+) Length 174 a.a.

Genomic Context

J9265_RS16085J9265_RS16090J9265_RS16095J9265_RS16100J9265_RS16105J9265_RS16110J9265_RS16115J9265_RS16120J9265_RS16125J9265_RS16130J9265_RS16135J9265_RS16140J9265_RS16155J9265_RS16160J9265_RS16165J9265_RS16145J9265_RS16150
Location: 426820..427737 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427894..428283 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428419..428628 (210 bp)
Type: Others
Protein ID: Protein_496
Location: 428747..429184 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429245..429466 (222 bp)
Type: Others
Protein ID: Protein_498
Location: 429641..430513 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430663..431262 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431319..431387 (69 bp)
Type: Others
Protein ID: Protein_501
Location: 431454..431723 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 431717..432238 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 432537..432662 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 432913..433308 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 434200..434715 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 434899..435312 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 435867..437044 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 433447..433725 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 433722..434006 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J9265_RS16085 (J9265_16085)426820..427737+918WP_000186333.1alpha/beta hydrolase-
J9265_RS16090 (J9265_16090)427894..428283+390WP_001081302.1hypothetical protein-
J9265_RS16095 (J9265_16095)428419..428628+210Protein_496GNAT family N-acetyltransferase-
J9265_RS16100 (J9265_16100)428747..429184+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
J9265_RS16105 (J9265_16105)429245..429466+222Protein_498GNAT family N-acetyltransferase-
J9265_RS16110 (J9265_16110)429641..430513+873WP_000254716.1DUF3800 domain-containing protein-
J9265_RS16115 (J9265_16115)430663..431262+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
J9265_RS16120 (J9265_16120)431319..431387+69Protein_501acetyltransferase-
J9265_RS16125 (J9265_16125)431454..431723+270WP_001114075.1DUF4160 domain-containing proteinToxin
J9265_RS16130 (J9265_16130)431717..432238+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
J9265_RS16135 (J9265_16135)432537..432662+126WP_001905700.1DUF645 family protein-
J9265_RS16140 (J9265_16140)432913..433308+396WP_001000867.1hypothetical protein-
J9265_RS16145 (J9265_16145)433447..433725-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
J9265_RS16150 (J9265_16150)433722..434006-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
J9265_RS16155 (J9265_16155)434200..434715+516WP_000343779.1GNAT family protein-
J9265_RS16160 (J9265_16160)434899..435312+414WP_000049420.1VOC family protein-
J9265_RS16165 (J9265_16165)435867..437044+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805
flankIS/Tn--428747..429184437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T198993 WP_001114075.1 NZ_CP072848:431454-431723 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T198993 NZ_CP097082:c2599971-2598649 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT198993 WP_000921691.1 NZ_CP072848:431717-432238 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT198993 NZ_CP097082:c2600237-2599971 [Klebsiella pneumoniae]
ATGAATTCCCCCCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGATGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References