23783

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 963694..964460 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag VCD_RS18950 Protein ID WP_000982260.1
Coordinates 963963..964460 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag VCD_RS18945 Protein ID WP_000246253.1
Coordinates 963694..963966 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS18905 958922..959839 - 918 WP_000186333.1 alpha/beta hydrolase -
VCD_RS18910 960073..960375 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCD_RS18915 960363..960620 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VCD_RS18920 960822..961355 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
VCD_RS21060 961352..961777 - 426 WP_001882332.1 DUF1778 domain-containing protein -
VCD_RS18930 961844..962215 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
VCD_RS18935 962356..962643 - 288 WP_000426470.1 hypothetical protein -
VCD_RS18940 962795..963463 - 669 WP_000043871.1 hypothetical protein -
VCD_RS18945 963694..963966 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
VCD_RS18950 963963..964460 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
VCD_RS18955 964662..964814 - 153 WP_001884520.1 DUF645 family protein -
VCD_RS18960 965136..965591 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
VCD_RS18965 965719..966006 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCD_RS18970 965996..966247 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VCD_RS18975 966461..966874 - 414 WP_000049417.1 VOC family protein -
VCD_RS20710 966949..967092 - 144 WP_071908341.1 DUF3265 domain-containing protein -
VCD_RS18980 967062..967463 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
VCD_RS18985 967463..968155 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
VCD_RS18990 968292..968598 - 307 Protein_849 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220
flank IS/Tn - - 968666..969646 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T23783 WP_000982260.1 NC_012667:963963-964460 [Vibrio cholerae MJ-1236]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T23783 NC_012667:963963-964460 [Vibrio cholerae MJ-1236]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT23783 WP_000246253.1 NC_012667:963694-963966 [Vibrio cholerae MJ-1236]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT23783 NC_012667:963694-963966 [Vibrio cholerae MJ-1236]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References