Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 963694..964460 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag VCD_RS18950 Protein ID WP_000982260.1
Coordinates 963963..964460 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag VCD_RS18945 Protein ID WP_000246253.1
Coordinates 963694..963966 (+) Length 91 a.a.

Genomic Context

VCD_RS18945VCD_RS18950VCD_RS18905VCD_RS18910VCD_RS18915VCD_RS18920VCD_RS21060VCD_RS18930VCD_RS18935VCD_RS18940VCD_RS18955VCD_RS18960VCD_RS18965VCD_RS18970VCD_RS18975VCD_RS20710VCD_RS18980VCD_RS18985VCD_RS18990
Location: 963694..963966 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 963963..964460 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 958922..959839 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 960073..960375 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 960363..960620 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 960822..961355 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 961352..961777 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 961844..962215 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 962356..962643 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 962795..963463 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 964662..964814 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 965136..965591 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 965719..966006 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 965996..966247 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 966461..966874 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 966949..967092 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 967062..967463 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 967463..968155 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 968292..968598 (307 bp)
Type: Others
Protein ID: Protein_849
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCD_RS18905958922..959839-918WP_000186333.1alpha/beta hydrolase-
VCD_RS18910960073..960375-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
VCD_RS18915960363..960620-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCD_RS18920960822..961355-534WP_000118351.1GNAT family N-acetyltransferase-
VCD_RS21060961352..961777-426WP_001882332.1DUF1778 domain-containing protein-
VCD_RS18930961844..962215-372WP_001164080.1nucleotide pyrophosphohydrolase-
VCD_RS18935962356..962643-288WP_000426470.1hypothetical protein-
VCD_RS18940962795..963463-669WP_000043871.1hypothetical protein-
VCD_RS18945963694..963966+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
VCD_RS18950963963..964460+498WP_000982260.1GNAT family N-acetyltransferaseToxin
VCD_RS18955964662..964814-153WP_001884520.1DUF645 family protein-
VCD_RS18960965136..965591-456WP_001245327.1GNAT family N-acetyltransferase-
VCD_RS18965965719..966006-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
VCD_RS18970965996..966247-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCD_RS18975966461..966874-414WP_000049417.1VOC family protein-
VCD_RS20710966949..967092-144WP_071908341.1DUF3265 domain-containing protein-
VCD_RS18980967062..967463-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
VCD_RS18985967463..968155-693WP_001047169.1GNAT family N-acetyltransferase-
VCD_RS18990968292..968598-307Protein_849CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932253..1057432125179
insideIntegron--958376..105059692220
flankIS/Tn--968666..969646980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T23783 WP_000982260.1 NC_012667:963963-964460 [Vibrio cholerae MJ-1236]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T23783 NC_012667:963963-964460 [Vibrio cholerae MJ-1236]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT23783 WP_000246253.1 NC_012667:963694-963966 [Vibrio cholerae MJ-1236]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT23783 NC_012667:963694-963966 [Vibrio cholerae MJ-1236]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References