294369

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 383262..384046 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag DG176_RS16065 Protein ID WP_001114075.1
Coordinates 383777..384046 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag DG176_RS16060 Protein ID WP_000921691.1
Coordinates 383262..383783 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG176_RS16020 380188..380601 - 414 WP_000049420.1 VOC family protein -
DG176_RS16030 380785..381300 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
DG176_RS16035 381494..381778 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
DG176_RS16040 381775..382053 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
DG176_RS16045 382192..382587 - 396 WP_001000867.1 hypothetical protein -
DG176_RS16055 382838..382963 - 126 WP_001905700.1 DUF645 family protein -
DG176_RS16060 383262..383783 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
DG176_RS16065 383777..384046 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
DG176_RS16070 384077..384181 - 105 WP_099607150.1 acetyltransferase -
DG176_RS16075 384238..384837 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
DG176_RS16080 384987..385859 - 873 WP_000254716.1 DUF3800 domain-containing protein -
DG176_RS16085 386034..386252 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
DG176_RS16090 386316..386753 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
DG176_RS16095 386872..387081 - 210 Protein_329 GNAT family N-acetyltransferase -
DG176_RS16100 387217..387606 - 390 WP_001081302.1 hypothetical protein -
DG176_RS16105 387763..388680 - 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 379325..476297 96972
flank IS/Tn - - 386316..386753 437
inside Integron catB9 - 379701..469509 89808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T294369 WP_001114075.1 NZ_LT992489:c384046-383777 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT294369 WP_000921691.1 NZ_LT992489:c383783-383262 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References