Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 507603..508162 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ87_RS16930 Protein ID WP_000578476.1
Coordinates 507603..507881 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ87_RS16935 Protein ID WP_000381183.1
Coordinates 507878..508162 (-) Length 95 a.a.

Genomic Context

ASZ87_RS16885ASZ87_RS16890ASZ87_RS16895ASZ87_RS16900ASZ87_RS16905ASZ87_RS16910ASZ87_RS16915ASZ87_RS16920ASZ87_RS16925ASZ87_RS16945ASZ87_RS16950ASZ87_RS16965ASZ87_RS16970ASZ87_RS16975ASZ87_RS16980ASZ87_RS16985ASZ87_RS16990ASZ87_RS16930ASZ87_RS16935
Location: 502681..503187 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 503344..503730 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 503987..504190 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 504385..504636 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 504609..504758 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 504905..505330 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 505536..506159 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 506372..506851 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 507039..507452 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 508357..508872 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 508937..509533 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 509925..510107 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 510307..510780 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 510795..510887 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 510929..511555 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 511678..512376 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 512386..512496 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 507603..507881 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 507878..508162 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS16885502681..503187+507WP_000393074.1hypothetical protein-
ASZ87_RS16890503344..503730+387WP_000703163.1VOC family protein-
ASZ87_RS16895503987..504190+204WP_001911580.1hypothetical protein-
ASZ87_RS16900504385..504636+252WP_001890111.1TIGR03643 family protein-
ASZ87_RS16905504609..504758+150WP_071908333.1DUF3265 domain-containing protein-
ASZ87_RS16910504905..505330+426WP_000415750.1hypothetical protein-
ASZ87_RS16915505536..506159+624WP_000247070.1DUF1349 domain-containing protein-
ASZ87_RS16920506372..506851+480WP_000009888.1lecithin retinol acyltransferase family protein-
ASZ87_RS16925507039..507452+414WP_000049420.1VOC family protein-
ASZ87_RS16930507603..507881-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
ASZ87_RS16935507878..508162-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ87_RS16945508357..508872+516WP_001201520.1lipocalin family protein-
ASZ87_RS16950508937..509533+597WP_000255434.1hypothetical protein-
ASZ87_RS16965509925..510107+183WP_000923182.1DUF645 family protein-
ASZ87_RS16970510307..510780+474WP_001161076.1GrpB family protein-
ASZ87_RS16975510795..510887+93WP_014378730.1DUF3265 domain-containing protein-
ASZ87_RS16980510929..511555+627WP_000365424.1LysE family translocator-
ASZ87_RS16985511678..512376+699WP_001890502.1hypothetical protein-
ASZ87_RS16990512386..512496+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58310 WP_000578476.1 NZ_CP013310:c507881-507603 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58310 NZ_CP013310:c507881-507603 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58310 WP_000381183.1 NZ_CP013310:c508162-507878 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58310 NZ_CP013310:c508162-507878 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References