74631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 861589..862167 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag A6J62_RS04560 Protein ID WP_001180243.1
Coordinates 861850..862167 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag A6J62_RS04555 Protein ID WP_000557292.1
Coordinates 861589..861831 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS04495 856983..857429 - 447 WP_000006157.1 hypothetical protein -
A6J62_RS19595 857625..857663 - 39 WP_106019118.1 hypothetical protein -
A6J62_RS04505 857679..857804 - 126 WP_001900195.1 DUF645 family protein -
A6J62_RS04510 858197..858469 + 273 WP_000246253.1 DUF1778 domain-containing protein -
A6J62_RS04515 858466..858963 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
A6J62_RS04520 859113..859628 - 516 WP_001201509.1 lipocalin family protein -
A6J62_RS04525 859765..860301 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
A6J62_RS04540 860559..860840 - 282 WP_001894429.1 DUF1289 domain-containing protein -
A6J62_RS04545 860789..860902 - 114 WP_001900214.1 hypothetical protein -
A6J62_RS04550 860959..861345 - 387 WP_001015867.1 NUDIX hydrolase -
A6J62_RS04555 861589..861831 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6J62_RS04560 861850..862167 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J62_RS04570 862321..862659 - 339 WP_000713853.1 hypothetical protein -
A6J62_RS04575 862817..863521 - 705 WP_000087610.1 HNH endonuclease -
A6J62_RS04580 863683..864891 - 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
A6J62_RS04585 865053..865730 - 678 WP_000254617.1 HNH endonuclease -
A6J62_RS04595 865925..866107 - 183 WP_000923153.1 DUF645 family protein -
A6J62_RS04600 866461..866643 - 183 WP_000923340.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T74631 WP_001180243.1 NZ_CP020407:861850-862167 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T74631 NZ_CP020407:861850-862167 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT74631 WP_000557292.1 NZ_CP020407:861589-861831 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT74631 NZ_CP020407:861589-861831 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References