199006

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 381375..382008 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag KAF59_RS15770 Protein ID WP_000843587.1
Coordinates 381375..381707 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KAF59_RS15775 Protein ID WP_000071008.1
Coordinates 381694..382008 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS18995 376610..376675 + 66 Protein_387 acetyltransferase -
KAF59_RS15715 (KAF59_15715) 376816..377019 + 204 WP_001911745.1 hypothetical protein -
KAF59_RS15720 (KAF59_15720) 377276..377473 + 198 WP_001894451.1 DUF3709 domain-containing protein -
KAF59_RS15725 (KAF59_15725) 377833..378102 + 270 WP_001198131.1 hypothetical protein -
KAF59_RS15730 (KAF59_15730) 378438..378591 + 154 Protein_391 DUF645 family protein -
KAF59_RS15735 (KAF59_15735) 378800..379186 + 387 WP_000703163.1 VOC family protein -
KAF59_RS15740 (KAF59_15740) 379388..379630 + 243 WP_000107461.1 hypothetical protein -
KAF59_RS15745 (KAF59_15745) 379801..380178 + 378 WP_000411109.1 hypothetical protein -
KAF59_RS15750 (KAF59_15750) 380235..380349 + 115 Protein_395 acetyltransferase -
KAF59_RS15755 (KAF59_15755) 380358..380579 + 222 WP_032468461.1 DUF1289 domain-containing protein -
KAF59_RS15760 (KAF59_15760) 380745..380858 + 114 WP_001889158.1 hypothetical protein -
KAF59_RS15765 (KAF59_15765) 380807..381034 + 228 WP_001894457.1 DUF1289 domain-containing protein -
KAF59_RS15770 (KAF59_15770) 381375..381707 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAF59_RS15775 (KAF59_15775) 381694..382008 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
KAF59_RS15780 (KAF59_15780) 382145..382579 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
KAF59_RS15785 (KAF59_15785) 382747..382902 + 156 WP_000751734.1 hypothetical protein -
KAF59_RS15790 (KAF59_15790) 383027..384007 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
KAF59_RS15795 (KAF59_15795) 384075..384381 + 307 Protein_404 CatB-related O-acetyltransferase -
KAF59_RS18900 384518..384916 + 399 Protein_405 GNAT family N-acetyltransferase -
KAF59_RS18905 385040..385210 + 171 WP_001080654.1 hypothetical protein -
KAF59_RS15805 (KAF59_15805) 385210..385611 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
KAF59_RS15810 (KAF59_15810) 385614..385724 + 111 WP_082798255.1 DUF3265 domain-containing protein -
KAF59_RS15815 (KAF59_15815) 385799..386212 + 414 WP_000049417.1 VOC family protein -
KAF59_RS15820 (KAF59_15820) 386426..386677 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KAF59_RS15825 (KAF59_15825) 386667..386954 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805
flank IS/Tn - - 383027..384007 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T199006 WP_000843587.1 NZ_CP072850:381375-381707 [Vibrio cholerae MO10]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T199006 NZ_CP097096:48722-48871 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT199006 WP_000071008.1 NZ_CP072850:381694-382008 [Vibrio cholerae MO10]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT199006 NZ_CP097096:c48678-48617 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References