Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 363251..363866 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag GPY07_RS16120 Protein ID WP_001162670.1
Coordinates 363579..363866 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GPY07_RS16115 Protein ID WP_001232701.1
Coordinates 363251..363568 (-) Length 106 a.a.

Genomic Context

GPY07_RS16150GPY07_RS16155GPY07_RS16070GPY07_RS16075GPY07_RS16080GPY07_RS16085GPY07_RS16090GPY07_RS16095GPY07_RS16100GPY07_RS16105GPY07_RS19445GPY07_RS16115GPY07_RS16120GPY07_RS16125GPY07_RS16130GPY07_RS16135GPY07_RS16140GPY07_RS16145GPY07_RS19450
Location: 367363..367605 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 367624..367941 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 358660..359175 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 359312..359788 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 359816..359926 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 359923..360852 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 360972..361418 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 361571..362575 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 362788..362826 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 362842..362967 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 363144..363254 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 363251..363568 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 363579..363866 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 364133..364313 (181 bp)
Type: Others
Protein ID: Protein_353
Location: 364738..364971 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 365374..365592 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 365902..366555 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 366612..367121 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 368135..368230 (96 bp)
Type: Others
Protein ID: WP_001907607.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY07_RS16070358660..359175-516WP_001201528.1lipocalin family protein-
GPY07_RS16075359312..359788-477WP_001047180.1GNAT family N-acetyltransferase-
GPY07_RS16080359816..359926-111WP_071917832.1DUF3265 domain-containing protein-
GPY07_RS16085359923..360852-930WP_000335802.1hypothetical protein-
GPY07_RS16090360972..361418-447WP_000128977.1hypothetical protein-
GPY07_RS16095361571..362575-1005WP_000964925.1LD-carboxypeptidase-
GPY07_RS16100362788..362826-39WP_106019119.1hypothetical protein-
GPY07_RS16105362842..362967-126WP_001944767.1DUF645 family protein-
GPY07_RS19445363144..363254-111WP_134814058.1DUF3265 domain-containing protein-
GPY07_RS16115363251..363568-318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
GPY07_RS16120363579..363866-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GPY07_RS16125364133..364313-181Protein_353DUF645 family protein-
GPY07_RS16130364738..364971-234WP_032482776.1DUF3709 domain-containing protein-
GPY07_RS16135365374..365592-219WP_001917086.1DUF3709 domain-containing protein-
GPY07_RS16140365902..366555-654WP_000226874.1hypothetical protein-
GPY07_RS16145366612..367121-510WP_000405987.1GNAT family N-acetyltransferase-
GPY07_RS16150367363..367605+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY07_RS16155367624..367941+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY07_RS19450368135..368230-96WP_001907607.1DUF645 family protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-322056..41902496968
insideIntegron--322432..41223689804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T145066 WP_001162670.1 NZ_CP046841:c363866-363579 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T145066 NZ_CP062252:5678900-5679178 [Pseudomonas allokribbensis]
ATGATCAAATCCTTTCAGCACAAAGGCCTTCGTGGCTTCTATGAAACCGGTTCGACTCGCGGGATTCGCGCCGATCACGC
TAAACGGCTGTCGCGTATGCTGCAGTTCATGGATCGGGCAGCGGTTCCCGGGGATCTGGACCTTCCCGGTTGGCGTCTGC
ATCCACTGAAAGGGGAACTTTGCGAGTACTGGTCACTGAGCGTGTCCGGGAACTGGCGGGTTATCTTTCGATTTGCAGGG
TCGGACATCGAACTGGTTGATTATCTGGATTACCACTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT145066 WP_001232701.1 NZ_CP046841:c363568-363251 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT145066 NZ_CP062252:5679193-5679480 [Pseudomonas allokribbensis]
ATGCCCATGCACAACCCGCCACACCCCGGTGAAACGCTGCTGATGGATGTATTGCCGGAGCTTGGTATCAGTGTCACCGA
ATTGGCTCGGCATCTCGGATTCGCCCGCCCTCACCTTTCTCGTGTATTGCACGGACATGCGCCGATCAGCCCGGATCTGG
CCGTACGACTGGAGCGCGCGGGGATTGGCAAGGCTCGTATGTGGCTAGGCGTTCAAACCGATTACGACCTTTGGCAAGCC
GAGCACCGCGAGCAGCCAGCCATTCAACCAATCGCTGCTCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References