Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 363251..363866 | Replicon | chromosome |
Accession | NZ_CP046841 | ||
Organism | Vibrio cholerae strain F9993 |
Toxin (Protein)
Gene name | higB | Uniprot ID | Q9KMG5 |
Locus tag | GPY07_RS16120 | Protein ID | WP_001162670.1 |
Coordinates | 363579..363866 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | GPY07_RS16115 | Protein ID | WP_001232701.1 |
Coordinates | 363251..363568 (-) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GPY07_RS16070 | 358660..359175 | - | 516 | WP_001201528.1 | lipocalin family protein | - |
GPY07_RS16075 | 359312..359788 | - | 477 | WP_001047180.1 | GNAT family N-acetyltransferase | - |
GPY07_RS16080 | 359816..359926 | - | 111 | WP_071917832.1 | DUF3265 domain-containing protein | - |
GPY07_RS16085 | 359923..360852 | - | 930 | WP_000335802.1 | hypothetical protein | - |
GPY07_RS16090 | 360972..361418 | - | 447 | WP_000128977.1 | hypothetical protein | - |
GPY07_RS16095 | 361571..362575 | - | 1005 | WP_000964925.1 | LD-carboxypeptidase | - |
GPY07_RS16100 | 362788..362826 | - | 39 | WP_106019119.1 | hypothetical protein | - |
GPY07_RS16105 | 362842..362967 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
GPY07_RS19445 | 363144..363254 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
GPY07_RS16115 | 363251..363568 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
GPY07_RS16120 | 363579..363866 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GPY07_RS16125 | 364133..364313 | - | 181 | Protein_353 | DUF645 family protein | - |
GPY07_RS16130 | 364738..364971 | - | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
GPY07_RS16135 | 365374..365592 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
GPY07_RS16140 | 365902..366555 | - | 654 | WP_000226874.1 | hypothetical protein | - |
GPY07_RS16145 | 366612..367121 | - | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
GPY07_RS16150 | 367363..367605 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
GPY07_RS16155 | 367624..367941 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
GPY07_RS19450 | 368135..368230 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 322056..419024 | 96968 | |
inside | Integron | - | - | 322432..412236 | 89804 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T145066 WP_001162670.1 NZ_CP046841:c363866-363579 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T145066 NZ_CP062252:5678900-5679178 [Pseudomonas allokribbensis]
ATGATCAAATCCTTTCAGCACAAAGGCCTTCGTGGCTTCTATGAAACCGGTTCGACTCGCGGGATTCGCGCCGATCACGC
TAAACGGCTGTCGCGTATGCTGCAGTTCATGGATCGGGCAGCGGTTCCCGGGGATCTGGACCTTCCCGGTTGGCGTCTGC
ATCCACTGAAAGGGGAACTTTGCGAGTACTGGTCACTGAGCGTGTCCGGGAACTGGCGGGTTATCTTTCGATTTGCAGGG
TCGGACATCGAACTGGTTGATTATCTGGATTACCACTGA
ATGATCAAATCCTTTCAGCACAAAGGCCTTCGTGGCTTCTATGAAACCGGTTCGACTCGCGGGATTCGCGCCGATCACGC
TAAACGGCTGTCGCGTATGCTGCAGTTCATGGATCGGGCAGCGGTTCCCGGGGATCTGGACCTTCCCGGTTGGCGTCTGC
ATCCACTGAAAGGGGAACTTTGCGAGTACTGGTCACTGAGCGTGTCCGGGAACTGGCGGGTTATCTTTCGATTTGCAGGG
TCGGACATCGAACTGGTTGATTATCTGGATTACCACTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT145066 WP_001232701.1 NZ_CP046841:c363568-363251 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT145066 NZ_CP062252:5679193-5679480 [Pseudomonas allokribbensis]
ATGCCCATGCACAACCCGCCACACCCCGGTGAAACGCTGCTGATGGATGTATTGCCGGAGCTTGGTATCAGTGTCACCGA
ATTGGCTCGGCATCTCGGATTCGCCCGCCCTCACCTTTCTCGTGTATTGCACGGACATGCGCCGATCAGCCCGGATCTGG
CCGTACGACTGGAGCGCGCGGGGATTGGCAAGGCTCGTATGTGGCTAGGCGTTCAAACCGATTACGACCTTTGGCAAGCC
GAGCACCGCGAGCAGCCAGCCATTCAACCAATCGCTGCTCACGCCTGA
ATGCCCATGCACAACCCGCCACACCCCGGTGAAACGCTGCTGATGGATGTATTGCCGGAGCTTGGTATCAGTGTCACCGA
ATTGGCTCGGCATCTCGGATTCGCCCGCCCTCACCTTTCTCGTGTATTGCACGGACATGCGCCGATCAGCCCGGATCTGG
CCGTACGACTGGAGCGCGCGGGGATTGGCAAGGCTCGTATGTGGCTAGGCGTTCAAACCGATTACGACCTTTGGCAAGCC
GAGCACCGCGAGCAGCCAGCCATTCAACCAATCGCTGCTCACGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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