92508

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 362915..363493 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag C1H56_RS16160 Protein ID WP_001180243.1
Coordinates 362915..363232 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag C1H56_RS16165 Protein ID WP_000557292.1
Coordinates 363251..363493 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H56_RS16110 358106..358501 + 396 WP_000046952.1 hypothetical protein -
C1H56_RS16115 358804..358985 + 182 Protein_346 DUF645 family protein -
C1H56_RS16120 359162..359557 + 396 WP_000046953.1 hypothetical protein -
C1H56_RS16125 359701..360237 + 537 WP_000644491.1 nucleotidyltransferase family protein -
C1H56_RS16130 360534..360713 + 180 WP_001883039.1 DUF645 family protein -
C1H56_RS16135 360909..361334 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
C1H56_RS16140 361483..361830 + 348 WP_000933409.1 hypothetical protein -
C1H56_RS19850 361977..362270 + 294 WP_125460920.1 hypothetical protein -
C1H56_RS19960 362626..362721 + 96 WP_001907607.1 DUF645 family protein -
C1H56_RS16160 362915..363232 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1H56_RS16165 363251..363493 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C1H56_RS16170 363735..364244 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
C1H56_RS16175 364301..364954 + 654 WP_000226874.1 hypothetical protein -
C1H56_RS16180 365264..365482 + 219 WP_001917086.1 DUF3709 domain-containing protein -
C1H56_RS16185 365885..366118 + 234 WP_032482776.1 DUF3709 domain-containing protein -
C1H56_RS16190 366543..366723 + 181 Protein_360 DUF645 family protein -
C1H56_RS16200 366990..367277 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
C1H56_RS16205 367288..367605 + 318 WP_001232701.1 HigA family addiction module antidote protein -
C1H56_RS19965 367602..367712 + 111 WP_134814058.1 DUF3265 domain-containing protein -
C1H56_RS16220 367889..368014 + 126 WP_001944767.1 DUF645 family protein -
C1H56_RS19855 368030..368068 + 39 WP_106019119.1 hypothetical protein -
C1H56_RS19970 368145..368246 + 102 Protein_366 exlusion protein FxsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304067..433328 129261
inside Integron catB9 - 309147..432952 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T92508 WP_001180243.1 NZ_CP025937:c363232-362915 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T92508 NZ_CP025937:c363232-362915 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT92508 WP_000557292.1 NZ_CP025937:c363493-363251 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT92508 NZ_CP025937:c363493-363251 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References