Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 71593..72208 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag K6J77_RS14425 Protein ID WP_001162670.1
Coordinates 71593..71880 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6J77_RS14430 Protein ID WP_001232701.1
Coordinates 71891..72208 (+) Length 106 a.a.

Genomic Context

K6J77_RS19030K6J77_RS19035K6J77_RS14400K6J77_RS14405K6J77_RS19040K6J77_RS14410K6J77_RS19045K6J77_RS14415K6J77_RS14420K6J77_RS19050K6J77_RS14425K6J77_RS14430K6J77_RS19055K6J77_RS19060K6J77_RS14435K6J77_RS19065K6J77_RS14445K6J77_RS14450K6J77_RS14455K6J77_RS19070K6J77_RS14460K6J77_RS14465K6J77_RS14390K6J77_RS14395
Location: 66936..67111 (176 bp)
Type: Others
Protein ID: Protein_122
Location: 67172..67324 (153 bp)
Type: Others
Protein ID: Protein_123
Location: 68338..68847 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 68904..69557 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 69646..69855 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 69867..70085 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 70274..70467 (194 bp)
Type: Others
Protein ID: Protein_130
Location: 70488..70721 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 71146..71326 (181 bp)
Type: Others
Protein ID: Protein_132
Location: 71439..71552 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 71593..71880 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 71891..72208 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 72205..72315 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 72354..72464 (111 bp)
Type: Others
Protein ID: Protein_137
Location: 72492..72617 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 72580..72696 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 72884..73888 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 74041..74487 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 74607..75536 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 75533..75643 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 75671..76147 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 76338..76799 (462 bp)
Type: Others
Protein ID: WP_001911752.1
Location: 67518..67835 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 67854..68096 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS1903066936..67111+176Protein_122acetyltransferase-
K6J77_RS1903567172..67324+153Protein_123DUF645 family protein-
K6J77_RS1439067518..67835-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J77_RS1439567854..68096-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J77_RS1440068338..68847+510WP_000405987.1GNAT family N-acetyltransferase-
K6J77_RS1440568904..69557+654WP_000226874.1hypothetical protein-
K6J77_RS1904069646..69855+210WP_001900246.1DUF3709 domain-containing protein-
K6J77_RS1441069867..70085+219WP_001917086.1DUF3709 domain-containing protein-
K6J77_RS1904570274..70467+194Protein_130hypothetical protein-
K6J77_RS1441570488..70721+234WP_032482776.1DUF3709 domain-containing protein-
K6J77_RS1442071146..71326+181Protein_132DUF645 family protein-
K6J77_RS1905071439..71552+114WP_001894955.1hypothetical protein-
K6J77_RS1442571593..71880+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J77_RS1443071891..72208+318WP_001232701.1HigA family addiction module antitoxinAntitoxin
K6J77_RS1905572205..72315+111WP_134814058.1DUF3265 domain-containing protein-
K6J77_RS1906072354..72464+111Protein_137acetyltransferase-
K6J77_RS1443572492..72617+126WP_001944767.1DUF645 family protein-
K6J77_RS1906572580..72696+117WP_001889170.1hypothetical protein-
K6J77_RS1444572884..73888+1005WP_000964925.1LD-carboxypeptidase-
K6J77_RS1445074041..74487+447WP_000128977.1hypothetical protein-
K6J77_RS1445574607..75536+930WP_000335802.1hypothetical protein-
K6J77_RS1907075533..75643+111WP_071917832.1DUF3265 domain-containing protein-
K6J77_RS1446075671..76147+477WP_001047180.1GNAT family N-acetyltransferase-
K6J77_RS1446576338..76799+462WP_001911752.1lipocalin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T38623 WP_001162670.1 NZ_AP024548:71593-71880 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T38623 NZ_AP024548:71593-71880 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT38623 WP_001232701.1 NZ_AP024548:71891-72208 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT38623 NZ_AP024548:71891-72208 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References