58306

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 487046..487624 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ87_RS16720 Protein ID WP_001180243.1
Coordinates 487046..487363 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ87_RS16725 Protein ID WP_000557292.1
Coordinates 487382..487624 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ87_RS16690 482570..482752 + 183 WP_000923340.1 DUF645 family protein -
ASZ87_RS16695 483106..483288 + 183 WP_000923153.1 DUF645 family protein -
ASZ87_RS16700 483483..484160 + 678 WP_000254617.1 HNH endonuclease -
ASZ87_RS16705 484322..485530 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
ASZ87_RS16710 485692..486396 + 705 WP_000087610.1 HNH endonuclease -
ASZ87_RS16715 486554..486892 + 339 WP_000713853.1 hypothetical protein -
ASZ87_RS16720 487046..487363 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ87_RS16725 487382..487624 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ87_RS16730 487868..488254 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ87_RS16735 488311..488424 + 114 WP_001900214.1 hypothetical protein -
ASZ87_RS16740 488373..488654 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ87_RS16750 488912..489448 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ87_RS16755 489585..490100 + 516 WP_001201509.1 lipocalin family protein -
ASZ87_RS16760 490250..490747 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ87_RS16765 490744..491016 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ87_RS20635 491409..491534 + 126 WP_001900195.1 DUF645 family protein -
ASZ87_RS20640 491550..491588 + 39 WP_106019118.1 hypothetical protein -
ASZ87_RS16775 491784..492230 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 435534..596659 161125
inside Integron - - 440614..596283 155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58306 WP_001180243.1 NZ_CP013310:c487363-487046 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58306 NZ_CP013310:c487363-487046 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58306 WP_000557292.1 NZ_CP013310:c487624-487382 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58306 NZ_CP013310:c487624-487382 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References