23795

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 1038458..1039036 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag VCD_RS19540 Protein ID WP_001180243.1
Coordinates 1038719..1039036 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag VCD_RS19535 Protein ID WP_000557292.1
Coordinates 1038458..1038700 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS19490 1033852..1034298 - 447 WP_000006157.1 hypothetical protein -
VCD_RS20945 1034494..1034532 - 39 WP_106019118.1 hypothetical protein -
VCD_RS20795 1034548..1034673 - 126 WP_001900195.1 DUF645 family protein -
VCD_RS19500 1035066..1035338 + 273 WP_000246253.1 DUF1778 domain-containing protein -
VCD_RS19505 1035335..1035832 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
VCD_RS19510 1035982..1036497 - 516 WP_001201509.1 lipocalin family protein -
VCD_RS19515 1036634..1037170 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
VCD_RS19525 1037428..1037709 - 282 WP_001894429.1 DUF1289 domain-containing protein -
VCD_RS20575 1037658..1037771 - 114 WP_001900214.1 hypothetical protein -
VCD_RS19530 1037828..1038214 - 387 WP_001015867.1 NUDIX hydrolase -
VCD_RS19535 1038458..1038700 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCD_RS19540 1038719..1039036 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCD_RS19545 1039190..1039528 - 339 WP_000713853.1 hypothetical protein -
VCD_RS19550 1039686..1040390 - 705 WP_000087610.1 HNH endonuclease -
VCD_RS19555 1040552..1041760 - 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
VCD_RS19560 1041922..1042599 - 678 WP_000254617.1 HNH endonuclease -
VCD_RS19565 1042794..1042976 - 183 WP_000923153.1 DUF645 family protein -
VCD_RS19575 1043330..1043512 - 183 WP_000923340.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T23795 WP_001180243.1 NC_012667:1038719-1039036 [Vibrio cholerae MJ-1236]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T23795 NC_012667:1038719-1039036 [Vibrio cholerae MJ-1236]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT23795 WP_000557292.1 NC_012667:1038458-1038700 [Vibrio cholerae MJ-1236]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT23795 NC_012667:1038458-1038700 [Vibrio cholerae MJ-1236]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References