Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 1038458..1039036 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag VCD_RS19540 Protein ID WP_001180243.1
Coordinates 1038719..1039036 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag VCD_RS19535 Protein ID WP_000557292.1
Coordinates 1038458..1038700 (+) Length 81 a.a.

Genomic Context

VCD_RS19500VCD_RS19505VCD_RS19535VCD_RS19540VCD_RS19490VCD_RS20945VCD_RS20795VCD_RS19510VCD_RS19515VCD_RS19525VCD_RS20575VCD_RS19530VCD_RS19545VCD_RS19550VCD_RS19555VCD_RS19560VCD_RS19565VCD_RS19575
Location: 1035066..1035338 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 1035335..1035832 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 1038458..1038700 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 1038719..1039036 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 1033852..1034298 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 1034494..1034532 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 1034548..1034673 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 1035982..1036497 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 1036634..1037170 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 1037428..1037709 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 1037658..1037771 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 1037828..1038214 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 1039190..1039528 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 1039686..1040390 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 1040552..1041760 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 1041922..1042599 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 1042794..1042976 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 1043330..1043512 (183 bp)
Type: Others
Protein ID: WP_000923340.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCD_RS194901033852..1034298-447WP_000006157.1hypothetical protein-
VCD_RS209451034494..1034532-39WP_106019118.1hypothetical protein-
VCD_RS207951034548..1034673-126WP_001900195.1DUF645 family protein-
VCD_RS195001035066..1035338+273WP_000246253.1DUF1778 domain-containing protein-
VCD_RS195051035335..1035832+498WP_000982260.1GNAT family N-acetyltransferase-
VCD_RS195101035982..1036497-516WP_001201509.1lipocalin family protein-
VCD_RS195151036634..1037170-537WP_000469482.1GNAT family N-acetyltransferase-
VCD_RS195251037428..1037709-282WP_001894429.1DUF1289 domain-containing protein-
VCD_RS205751037658..1037771-114WP_001900214.1hypothetical protein-
VCD_RS195301037828..1038214-387WP_001015867.1NUDIX hydrolase-
VCD_RS195351038458..1038700+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
VCD_RS195401038719..1039036+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCD_RS195451039190..1039528-339WP_000713853.1hypothetical protein-
VCD_RS195501039686..1040390-705WP_000087610.1HNH endonuclease-
VCD_RS195551040552..1041760-1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
VCD_RS195601041922..1042599-678WP_000254617.1HNH endonuclease-
VCD_RS195651042794..1042976-183WP_000923153.1DUF645 family protein-
VCD_RS195751043330..1043512-183WP_000923340.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932253..1057432125179
insideIntegron--958376..105059692220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T23795 WP_001180243.1 NC_012667:1038719-1039036 [Vibrio cholerae MJ-1236]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T23795 NC_012667:1038719-1039036 [Vibrio cholerae MJ-1236]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT23795 WP_000557292.1 NC_012667:1038458-1038700 [Vibrio cholerae MJ-1236]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT23795 NC_012667:1038458-1038700 [Vibrio cholerae MJ-1236]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References