Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 340891..341741 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag ASZ81_RS15910 Protein ID WP_000118351.1
Coordinates 341208..341741 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ81_RS15905 Protein ID WP_001909340.1
Coordinates 340891..341211 (+) Length 107 a.a.

Genomic Context

ASZ81_RS15865ASZ81_RS15875ASZ81_RS15880ASZ81_RS20435ASZ81_RS15885ASZ81_RS15890ASZ81_RS20440ASZ81_RS15895ASZ81_RS15905ASZ81_RS15910ASZ81_RS15915ASZ81_RS15920ASZ81_RS15930ASZ81_RS15935ASZ81_RS15940ASZ81_RS15945
Location: 336227..336709 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 337517..337786 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 337780..338301 (522 bp)
Type: Others
Protein ID: WP_000921692.1
Location: 338358..338471 (114 bp)
Type: Others
Protein ID: WP_001894981.1
Location: 338440..339276 (837 bp)
Type: Others
Protein ID: WP_000242986.1
Location: 339441..340079 (639 bp)
Type: Others
Protein ID: WP_000230118.1
Location: 340169..340329 (161 bp)
Type: Others
Protein ID: Protein_308
Location: 340350..340571 (222 bp)
Type: Others
Protein ID: WP_012705854.1
Location: 340891..341211 (321 bp)
Type: Antitoxin
Protein ID: WP_001909340.1
Location: 341208..341741 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 341979..342257 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 342658..342882 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 343620..344009 (390 bp)
Type: Others
Protein ID: WP_000491263.1
Location: 344142..344657 (516 bp)
Type: Others
Protein ID: WP_000090008.1
Location: 344798..345235 (438 bp)
Type: Others
Protein ID: WP_001202554.1
Location: 345396..345743 (348 bp)
Type: Others
Protein ID: WP_000933409.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS15865336227..336709+483WP_000422940.1GNAT family N-acetyltransferase-
ASZ81_RS15875337517..337786+270WP_001114075.1DUF4160 domain-containing protein-
ASZ81_RS15880337780..338301+522WP_000921692.1DUF2442 domain-containing protein-
ASZ81_RS20435338358..338471+114WP_001894981.1hypothetical protein-
ASZ81_RS15885338440..339276+837WP_000242986.1hypothetical protein-
ASZ81_RS15890339441..340079+639WP_000230118.1HD domain-containing protein-
ASZ81_RS20440340169..340329+161Protein_308DUF3709 domain-containing protein-
ASZ81_RS15895340350..340571+222WP_012705854.1DUF3709 domain-containing protein-
ASZ81_RS15905340891..341211+321WP_001909340.1DUF1778 domain-containing proteinAntitoxin
ASZ81_RS15910341208..341741+534WP_000118351.1GNAT family N-acetyltransferaseToxin
ASZ81_RS15915341979..342257+279WP_000280324.1DUF3709 domain-containing protein-
ASZ81_RS15920342658..342882+225WP_001894423.1DUF3709 domain-containing protein-
ASZ81_RS15930343620..344009+390WP_000491263.1VOC family protein-
ASZ81_RS15935344142..344657+516WP_000090008.1hypothetical protein-
ASZ81_RS15940344798..345235+438WP_001202554.1NUDIX pyrophosphatase-
ASZ81_RS15945345396..345743+348WP_000933409.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(22-98)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T58262 WP_000118351.1 NZ_CP013306:341208-341741 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T58262 NZ_CP013306:341208-341741 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11759.53 Da        Isoelectric Point: 4.9309

>AT58262 WP_001909340.1 NZ_CP013306:340891-341211 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 321 bp

>AT58262 NZ_CP013306:340891-341211 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References