Detailed information of TA system TA058262

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 340891..341741
• Replicon: chromosome
• Accession: NZ_CP013306
• Organism: Vibrio cholerae strain CRC1106

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: ASZ81_RS15910
• Protein ID: WP_000118351.1
• Coordinates: 341208..341741 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ASZ81_RS15905
• Protein ID: WP_001909340.1
• Coordinates: 340891..341211 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ81_RS15865	336227..336709	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ81_RS15875	337517..337786	+	270	WP_001114075.1	DUF4160 domain-containing protein	-
ASZ81_RS15880	337780..338301	+	522	WP_000921692.1	DUF2442 domain-containing protein	-
ASZ81_RS20435	338358..338471	+	114	WP_001894981.1	hypothetical protein	-
ASZ81_RS15885	338440..339276	+	837	WP_000242986.1	hypothetical protein	-
ASZ81_RS15890	339441..340079	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ81_RS20440	340169..340329	+	161	Protein_308	DUF3709 domain-containing protein	-
ASZ81_RS15895	340350..340571	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ81_RS15905	340891..341211	+	321	WP_001909340.1	DUF1778 domain-containing protein	Antitoxin
ASZ81_RS15910	341208..341741	+	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
ASZ81_RS15915	341979..342257	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ81_RS15920	342658..342882	+	225	WP_001894423.1	DUF3709 domain-containing protein	-
ASZ81_RS15930	343620..344009	+	390	WP_000491263.1	VOC family protein	-
ASZ81_RS15935	344142..344657	+	516	WP_000090008.1	hypothetical protein	-
ASZ81_RS15940	344798..345235	+	438	WP_001202554.1	NUDIX pyrophosphatase	-
ASZ81_RS15945	345396..345743	+	348	WP_000933409.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304741..463550	158809
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.006	inside	Integron	-	-	309821..463174	153353

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (22-98)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T58262 WP_000118351.1 NZ_CP013306:341208-341741 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T58262 NZ_CP013306:341208-341741 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11759.53 Da
• Isoelectric Point: 4.9309

>AT58262 WP_001909340.1 NZ_CP013306:340891-341211 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 321 bp

>AT58262 NZ_CP013306:340891-341211 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A

Structures

Toxin

• AlphaFold DB: Q9KM94