Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 393138..393716 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ81_RS16420 Protein ID WP_001180243.1
Coordinates 393138..393455 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ81_RS16425 Protein ID WP_000557292.1
Coordinates 393474..393716 (-) Length 81 a.a.

Genomic Context

ASZ81_RS16365ASZ81_RS16370ASZ81_RS16375ASZ81_RS16380ASZ81_RS16385ASZ81_RS16390ASZ81_RS16395ASZ81_RS16400ASZ81_RS20565ASZ81_RS20935ASZ81_RS16430ASZ81_RS16435ASZ81_RS16440ASZ81_RS16450ASZ81_RS16455ASZ81_RS16460ASZ81_RS16465ASZ81_RS20940ASZ81_RS20945ASZ81_RS20950ASZ81_RS16420ASZ81_RS16425
Location: 388179..388319 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 388329..388724 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 389027..389208 (182 bp)
Type: Others
Protein ID: Protein_397
Location: 389385..389780 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 389924..390460 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 390757..390936 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 391132..391557 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 391706..392053 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 392200..392493 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 392849..392944 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 393958..394467 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 394524..395177 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 395487..395705 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 396108..396341 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 396766..396946 (181 bp)
Type: Others
Protein ID: Protein_411
Location: 397213..397500 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 397511..397828 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 397825..397935 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 398112..398237 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 398253..398291 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 393138..393455 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 393474..393716 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS16365388179..388319+141WP_001883049.1DUF3265 domain-containing protein-
ASZ81_RS16370388329..388724+396WP_000046952.1hypothetical protein-
ASZ81_RS16375389027..389208+182Protein_397DUF645 family protein-
ASZ81_RS16380389385..389780+396WP_000046953.1hypothetical protein-
ASZ81_RS16385389924..390460+537WP_000644491.1nucleotidyltransferase family protein-
ASZ81_RS16390390757..390936+180WP_001883039.1DUF645 family protein-
ASZ81_RS16395391132..391557+426WP_000403014.1GNAT family N-acetyltransferase-
ASZ81_RS16400391706..392053+348WP_000933409.1hypothetical protein-
ASZ81_RS20565392200..392493+294WP_125460920.1hypothetical protein-
ASZ81_RS20935392849..392944+96WP_001907607.1DUF645 family protein-
ASZ81_RS16420393138..393455-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ81_RS16425393474..393716-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ81_RS16430393958..394467+510WP_000405987.1GNAT family N-acetyltransferase-
ASZ81_RS16435394524..395177+654WP_000226874.1hypothetical protein-
ASZ81_RS16440395487..395705+219WP_001917086.1DUF3709 domain-containing protein-
ASZ81_RS16450396108..396341+234WP_032482776.1DUF3709 domain-containing protein-
ASZ81_RS16455396766..396946+181Protein_411DUF645 family protein-
ASZ81_RS16460397213..397500+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS16465397511..397828+318WP_001232701.1HigA family addiction module antidote protein-
ASZ81_RS20940397825..397935+111WP_134814058.1DUF3265 domain-containing protein-
ASZ81_RS20945398112..398237+126WP_001944767.1DUF645 family protein-
ASZ81_RS20950398253..398291+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58269 WP_001180243.1 NZ_CP013306:c393455-393138 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58269 NZ_CP013306:c393455-393138 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58269 WP_000557292.1 NZ_CP013306:c393716-393474 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58269 NZ_CP013306:c393716-393474 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References