Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 393138..393716 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ81_RS16420 Protein ID WP_001180243.1
Coordinates 393138..393455 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ81_RS16425 Protein ID WP_000557292.1
Coordinates 393474..393716 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ81_RS16365 388179..388319 + 141 WP_001883049.1 DUF3265 domain-containing protein -
ASZ81_RS16370 388329..388724 + 396 WP_000046952.1 hypothetical protein -
ASZ81_RS16375 389027..389208 + 182 Protein_397 DUF645 family protein -
ASZ81_RS16380 389385..389780 + 396 WP_000046953.1 hypothetical protein -
ASZ81_RS16385 389924..390460 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ81_RS16390 390757..390936 + 180 WP_001883039.1 DUF645 family protein -
ASZ81_RS16395 391132..391557 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
ASZ81_RS16400 391706..392053 + 348 WP_000933409.1 hypothetical protein -
ASZ81_RS20565 392200..392493 + 294 WP_125460920.1 hypothetical protein -
ASZ81_RS20935 392849..392944 + 96 WP_001907607.1 DUF645 family protein -
ASZ81_RS16420 393138..393455 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ81_RS16425 393474..393716 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ81_RS16430 393958..394467 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
ASZ81_RS16435 394524..395177 + 654 WP_000226874.1 hypothetical protein -
ASZ81_RS16440 395487..395705 + 219 WP_001917086.1 DUF3709 domain-containing protein -
ASZ81_RS16450 396108..396341 + 234 WP_032482776.1 DUF3709 domain-containing protein -
ASZ81_RS16455 396766..396946 + 181 Protein_411 DUF645 family protein -
ASZ81_RS16460 397213..397500 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ81_RS16465 397511..397828 + 318 WP_001232701.1 HigA family addiction module antidote protein -
ASZ81_RS20940 397825..397935 + 111 WP_134814058.1 DUF3265 domain-containing protein -
ASZ81_RS20945 398112..398237 + 126 WP_001944767.1 DUF645 family protein -
ASZ81_RS20950 398253..398291 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304741..463550 158809
inside Integron - - 309821..463174 153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58269 WP_001180243.1 NZ_CP013306:c393455-393138 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58269 NZ_CP013306:c393455-393138 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58269 WP_000557292.1 NZ_CP013306:c393716-393474 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58269 NZ_CP013306:c393716-393474 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References