Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 409942..410501 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag IT766_RS15615 Protein ID WP_000578476.1
Coordinates 409942..410220 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag IT766_RS15620 Protein ID WP_000381183.1
Coordinates 410217..410501 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS15570 404979..405212 + 234 WP_001890112.1 DUF3709 domain-containing protein -
IT766_RS15575 405480..405986 + 507 WP_000393074.1 hypothetical protein -
IT766_RS15580 406143..406529 + 387 WP_000703163.1 VOC family protein -
IT766_RS15585 406724..406975 + 252 WP_001890111.1 TIGR03643 family protein -
IT766_RS15590 406948..407097 + 150 WP_071908333.1 DUF3265 domain-containing protein -
IT766_RS15595 407244..407669 + 426 WP_000415750.1 hypothetical protein -
IT766_RS15600 407875..408498 + 624 WP_000247070.1 DUF1349 domain-containing protein -
IT766_RS15605 408711..409190 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
IT766_RS15610 409378..409791 + 414 WP_000049420.1 VOC family protein -
IT766_RS15615 409942..410220 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
IT766_RS15620 410217..410501 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IT766_RS15625 410696..411211 + 516 WP_001201520.1 lipocalin family protein -
IT766_RS15630 411276..411872 + 597 WP_000255434.1 hypothetical protein -
IT766_RS15635 412264..412446 + 183 WP_000923182.1 DUF645 family protein -
IT766_RS15640 412646..413119 + 474 WP_001161076.1 GrpB family protein -
IT766_RS15645 413134..413226 + 93 WP_014378730.1 DUF3265 domain-containing protein -
IT766_RS15650 413268..413894 + 627 WP_000365424.1 LysE family translocator -
IT766_RS15655 414017..414715 + 699 WP_001890502.1 hypothetical protein -
IT766_RS15660 414725..414835 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T180869 WP_000578476.1 NZ_CP064351:c410220-409942 [Vibrio cholerae C6706]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T180869 NZ_CP085767:c1892080-1891709 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT180869 WP_000381183.1 NZ_CP064351:c410501-410217 [Vibrio cholerae C6706]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT180869 NZ_CP085767:c1892325-1892083 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAACCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References