Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 320707..321285 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag C1H56_RS15695 Protein ID WP_001180243.1
Coordinates 320707..321024 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag C1H56_RS15700 Protein ID WP_000557292.1
Coordinates 321043..321285 (-) Length 81 a.a.

Genomic Context

C1H56_RS15655C1H56_RS15660C1H56_RS15670C1H56_RS15675C1H56_RS15680C1H56_RS15685C1H56_RS15705C1H56_RS15710C1H56_RS15715C1H56_RS15730C1H56_RS15735C1H56_RS15750C1H56_RS19830C1H56_RS15760C1H56_RS15695C1H56_RS15700C1H56_RS15740C1H56_RS15745
Location: 316231..316413 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 316767..316949 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 317144..317821 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 317983..319191 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 319353..320057 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 320215..320553 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 321529..321915 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 321972..322085 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322034..322315 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 322573..323109 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323246..323761 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 325070..325195 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 325211..325249 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 325445..325891 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 320707..321024 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 321043..321285 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 323911..324408 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 324405..324677 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS15655316231..316413+183WP_000923340.1DUF645 family protein-
C1H56_RS15660316767..316949+183WP_000923153.1DUF645 family protein-
C1H56_RS15670317144..317821+678WP_000254617.1HNH endonuclease-
C1H56_RS15675317983..319191+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
C1H56_RS15680319353..320057+705WP_000087610.1HNH endonuclease-
C1H56_RS15685320215..320553+339WP_000713853.1hypothetical protein-
C1H56_RS15695320707..321024-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C1H56_RS15700321043..321285-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
C1H56_RS15705321529..321915+387WP_001015867.1NUDIX hydrolase-
C1H56_RS15710321972..322085+114WP_001900214.1hypothetical protein-
C1H56_RS15715322034..322315+282WP_001894429.1DUF1289 domain-containing protein-
C1H56_RS15730322573..323109+537WP_000469482.1GNAT family N-acetyltransferase-
C1H56_RS15735323246..323761+516WP_001201509.1lipocalin family protein-
C1H56_RS15740323911..324408-498WP_000982260.1GNAT family N-acetyltransferase-
C1H56_RS15745324405..324677-273WP_000246253.1DUF1778 domain-containing protein-
C1H56_RS15750325070..325195+126WP_001900195.1DUF645 family protein-
C1H56_RS19830325211..325249+39WP_106019118.1hypothetical protein-
C1H56_RS15760325445..325891+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T92502 WP_001180243.1 NZ_CP025937:c321024-320707 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T92502 NZ_CP025937:c321024-320707 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT92502 WP_000557292.1 NZ_CP025937:c321285-321043 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT92502 NZ_CP025937:c321285-321043 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References