92502

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 320707..321285 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag C1H56_RS15695 Protein ID WP_001180243.1
Coordinates 320707..321024 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag C1H56_RS15700 Protein ID WP_000557292.1
Coordinates 321043..321285 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H56_RS15655 316231..316413 + 183 WP_000923340.1 DUF645 family protein -
C1H56_RS15660 316767..316949 + 183 WP_000923153.1 DUF645 family protein -
C1H56_RS15670 317144..317821 + 678 WP_000254617.1 HNH endonuclease -
C1H56_RS15675 317983..319191 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
C1H56_RS15680 319353..320057 + 705 WP_000087610.1 HNH endonuclease -
C1H56_RS15685 320215..320553 + 339 WP_000713853.1 hypothetical protein -
C1H56_RS15695 320707..321024 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1H56_RS15700 321043..321285 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C1H56_RS15705 321529..321915 + 387 WP_001015867.1 NUDIX hydrolase -
C1H56_RS15710 321972..322085 + 114 WP_001900214.1 hypothetical protein -
C1H56_RS15715 322034..322315 + 282 WP_001894429.1 DUF1289 domain-containing protein -
C1H56_RS15730 322573..323109 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
C1H56_RS15735 323246..323761 + 516 WP_001201509.1 lipocalin family protein -
C1H56_RS15740 323911..324408 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
C1H56_RS15745 324405..324677 - 273 WP_000246253.1 DUF1778 domain-containing protein -
C1H56_RS15750 325070..325195 + 126 WP_001900195.1 DUF645 family protein -
C1H56_RS19830 325211..325249 + 39 WP_106019118.1 hypothetical protein -
C1H56_RS15760 325445..325891 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304067..433328 129261
inside Integron catB9 - 309147..432952 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T92502 WP_001180243.1 NZ_CP025937:c321024-320707 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T92502 NZ_CP025937:c321024-320707 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT92502 WP_000557292.1 NZ_CP025937:c321285-321043 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT92502 NZ_CP025937:c321285-321043 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References