Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 337479..337977 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GTF71_RS14990 Protein ID WP_000589156.1
Coordinates 337479..337745 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GTF71_RS14995 Protein ID WP_000643598.1
Coordinates 337732..337977 (+) Length 82 a.a.

Genomic Context

GTF71_RS14935GTF71_RS14940GTF71_RS14945GTF71_RS14950GTF71_RS14955GTF71_RS14960GTF71_RS14965GTF71_RS14970GTF71_RS14975GTF71_RS14980GTF71_RS14985GTF71_RS14990GTF71_RS14995GTF71_RS15000GTF71_RS15005GTF71_RS15010GTF71_RS15015GTF71_RS15020GTF71_RS15025GTF71_RS15030GTF71_RS15035
Location: 332900..333106 (207 bp)
Type: Others
Protein ID: Protein_297
Location: 333306..333407 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 333397..333783 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 333978..334229 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 334202..334351 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 334443..334685 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 334937..335215 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 335590..335733 (144 bp)
Type: Others
Protein ID: Protein_304
Location: 335787..335825 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 336037..336504 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 336632..337294 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 337479..337745 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 337732..337977 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 338073..338867 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 338970..339098 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 339159..339341 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 339557..340561 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 340714..341073 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 341346..341579 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 341847..342353 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 342510..342896 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF71_RS14935332900..333106+207Protein_297DUF3709 domain-containing protein-
GTF71_RS14940333306..333407+102WP_001921603.1hypothetical protein-
GTF71_RS14945333397..333783+387WP_000703163.1VOC family protein-
GTF71_RS14950333978..334229+252WP_001890111.1TIGR03643 family protein-
GTF71_RS14955334202..334351+150WP_071908333.1DUF3265 domain-containing protein-
GTF71_RS14960334443..334685+243WP_000107461.1hypothetical protein-
GTF71_RS14965334937..335215+279WP_000280324.1DUF3709 domain-containing protein-
GTF71_RS14970335590..335733+144Protein_304DUF645 family protein-
GTF71_RS14975335787..335825+39WP_082798268.1hypothetical protein-
GTF71_RS14980336037..336504+468WP_001289288.1OsmC family protein-
GTF71_RS14985336632..337294+663WP_000960654.1hypothetical protein-
GTF71_RS14990337479..337745+267WP_000589156.1BrnT family toxinToxin
GTF71_RS14995337732..337977+246WP_000643598.1hypothetical proteinAntitoxin
GTF71_RS15000338073..338867+795WP_001911581.1hypothetical protein-
GTF71_RS15005338970..339098+129WP_071908338.1general secretion pathway protein GspI-
GTF71_RS15010339159..339341+183WP_000923182.1DUF645 family protein-
GTF71_RS15015339557..340561+1005WP_000964920.1LD-carboxypeptidase-
GTF71_RS15020340714..341073+360WP_001071541.1VOC family protein-
GTF71_RS15025341346..341579+234WP_001890112.1DUF3709 domain-containing protein-
GTF71_RS15030341847..342353+507WP_000393074.1hypothetical protein-
GTF71_RS15035342510..342896+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306926..439292132366
insideIntegron--312006..438916126910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T145846 WP_000589156.1 NZ_CP047300:337479-337745 [Vibrio cholerae O1 biovar El Tor]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T145846 NZ_CP062702:c3305701-3305327 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT145846 WP_000643598.1 NZ_CP047300:337732-337977 [Vibrio cholerae O1 biovar El Tor]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT145846 NZ_CP062702:c3306122-3305748 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References