104252

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 351937..352475 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag N16961_RS15825 Protein ID WP_000802136.1
Coordinates 351937..352236 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag N16961_RS15830 Protein ID WP_001107719.1
Coordinates 352233..352475 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N16961_RS15775 347872..348054 + 183 WP_000923182.1 DUF645 family protein -
N16961_RS15780 348254..348727 + 474 WP_001161076.1 GrpB family protein -
N16961_RS15785 348742..348834 + 93 WP_014378730.1 DUF3265 domain-containing protein -
N16961_RS15790 348876..349502 + 627 WP_000365424.1 LysE family translocator -
N16961_RS15795 349625..350323 + 699 WP_001890502.1 hypothetical protein -
N16961_RS15800 350333..350443 + 111 WP_079857360.1 DUF3265 domain-containing protein -
N16961_RS15815 351021..351200 + 180 WP_001883058.1 DUF645 family protein -
N16961_RS15820 351414..351809 + 396 WP_000870857.1 DUF3465 domain-containing protein -
N16961_RS15825 351937..352236 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N16961_RS15830 352233..352475 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
N16961_RS15840 352704..353282 + 579 WP_000110120.1 hypothetical protein -
N16961_RS15845 353304..353396 + 93 WP_014164112.1 DUF3265 domain-containing protein -
N16961_RS15855 353820..354503 + 684 WP_000877436.1 hypothetical protein -
N16961_RS15865 354717..354983 + 267 WP_000937852.1 hypothetical protein -
N16961_RS15875 355138..355737 + 600 WP_000429495.1 hypothetical protein -
N16961_RS15880 356018..356953 + 936 WP_000051985.1 restriction endonuclease -
N16961_RS15885 356919..357059 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306977..438073 131096
inside Integron - - 312057..437697 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T104252 WP_000802136.1 NZ_CP028828:c352236-351937 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T104252 NZ_CP028828:c352236-351937 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT104252 WP_001107719.1 NZ_CP028828:c352475-352233 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT104252 NZ_CP028828:c352475-352233 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References