Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 351937..352475 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag N16961_RS15825 Protein ID WP_000802136.1
Coordinates 351937..352236 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag N16961_RS15830 Protein ID WP_001107719.1
Coordinates 352233..352475 (-) Length 81 a.a.

Genomic Context

N16961_RS15775N16961_RS15780N16961_RS15785N16961_RS15790N16961_RS15795N16961_RS15800N16961_RS15815N16961_RS15820N16961_RS15840N16961_RS15845N16961_RS15855N16961_RS15865N16961_RS15875N16961_RS15880N16961_RS15885N16961_RS15825N16961_RS15830
Location: 347872..348054 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 348254..348727 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 348742..348834 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 348876..349502 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 349625..350323 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 350333..350443 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 351021..351200 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 351414..351809 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 352704..353282 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 353304..353396 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 353820..354503 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 354717..354983 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 355138..355737 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 356018..356953 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 356919..357059 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 351937..352236 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 352233..352475 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS15775347872..348054+183WP_000923182.1DUF645 family protein-
N16961_RS15780348254..348727+474WP_001161076.1GrpB family protein-
N16961_RS15785348742..348834+93WP_014378730.1DUF3265 domain-containing protein-
N16961_RS15790348876..349502+627WP_000365424.1LysE family translocator-
N16961_RS15795349625..350323+699WP_001890502.1hypothetical protein-
N16961_RS15800350333..350443+111WP_079857360.1DUF3265 domain-containing protein-
N16961_RS15815351021..351200+180WP_001883058.1DUF645 family protein-
N16961_RS15820351414..351809+396WP_000870857.1DUF3465 domain-containing protein-
N16961_RS15825351937..352236-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N16961_RS15830352233..352475-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
N16961_RS15840352704..353282+579WP_000110120.1hypothetical protein-
N16961_RS15845353304..353396+93WP_014164112.1DUF3265 domain-containing protein-
N16961_RS15855353820..354503+684WP_000877436.1hypothetical protein-
N16961_RS15865354717..354983+267WP_000937852.1hypothetical protein-
N16961_RS15875355138..355737+600WP_000429495.1hypothetical protein-
N16961_RS15880356018..356953+936WP_000051985.1restriction endonuclease-
N16961_RS15885356919..357059+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T104252 WP_000802136.1 NZ_CP028828:c352236-351937 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T104252 NZ_CP028828:c352236-351937 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT104252 WP_001107719.1 NZ_CP028828:c352475-352233 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT104252 NZ_CP028828:c352475-352233 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References