Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 422199..422965 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag A1552VC_RS16810 Protein ID WP_000982260.1
Coordinates 422199..422696 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag A1552VC_RS16815 Protein ID WP_000246253.1
Coordinates 422693..422965 (-) Length 91 a.a.

Genomic Context

A1552VC_RS16760A1552VC_RS16765A1552VC_RS16770A1552VC_RS16775A1552VC_RS16780A1552VC_RS16785A1552VC_RS16790A1552VC_RS16795A1552VC_RS16800A1552VC_RS16820A1552VC_RS16825A1552VC_RS16830A1552VC_RS16835A1552VC_RS16840A1552VC_RS16850A1552VC_RS16855A1552VC_RS16860A1552VC_RS16810A1552VC_RS16815
Location: 418061..418367 (307 bp)
Type: Others
Protein ID: Protein_445
Location: 418504..419196 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 419196..419597 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419567..419710 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419785..420198 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420412..420663 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420653..420940 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 421068..421523 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421845..421997 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423196..423864 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424016..424303 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424444..424815 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424882..425307 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 425304..425837 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 426039..426296 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 426284..426586 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 426820..427737 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 422199..422696 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 422693..422965 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS16760418061..418367+307Protein_445CatB-related O-acetyltransferase-
A1552VC_RS16765418504..419196+693WP_001047169.1GNAT family N-acetyltransferase-
A1552VC_RS16770419196..419597+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
A1552VC_RS16775419567..419710+144WP_071908341.1DUF3265 domain-containing protein-
A1552VC_RS16780419785..420198+414WP_000049417.1VOC family protein-
A1552VC_RS16785420412..420663+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
A1552VC_RS16790420653..420940+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
A1552VC_RS16795421068..421523+456WP_001245327.1GNAT family N-acetyltransferase-
A1552VC_RS16800421845..421997+153WP_001884520.1DUF645 family protein-
A1552VC_RS16810422199..422696-498WP_000982260.1GNAT family N-acetyltransferaseToxin
A1552VC_RS16815422693..422965-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
A1552VC_RS16820423196..423864+669WP_000043871.1hypothetical protein-
A1552VC_RS16825424016..424303+288WP_000426470.1hypothetical protein-
A1552VC_RS16830424444..424815+372WP_001164080.1nucleotide pyrophosphohydrolase-
A1552VC_RS16835424882..425307+426WP_001882332.1DUF1778 domain-containing protein-
A1552VC_RS16840425304..425837+534WP_000118351.1GNAT family N-acetyltransferase-
A1552VC_RS16850426039..426296+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
A1552VC_RS16855426284..426586+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
A1552VC_RS16860426820..427737+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805
flankIS/Tn--417013..417993980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T104347 WP_000982260.1 NZ_CP028895:c422696-422199 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T104347 NZ_CP028895:c422696-422199 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT104347 WP_000246253.1 NZ_CP028895:c422965-422693 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT104347 NZ_CP028895:c422965-422693 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References