104347

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 422199..422965 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag A1552VC_RS16810 Protein ID WP_000982260.1
Coordinates 422199..422696 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag A1552VC_RS16815 Protein ID WP_000246253.1
Coordinates 422693..422965 (-) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1552VC_RS16760 418061..418367 + 307 Protein_445 CatB-related O-acetyltransferase -
A1552VC_RS16765 418504..419196 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
A1552VC_RS16770 419196..419597 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
A1552VC_RS16775 419567..419710 + 144 WP_071908341.1 DUF3265 domain-containing protein -
A1552VC_RS16780 419785..420198 + 414 WP_000049417.1 VOC family protein -
A1552VC_RS16785 420412..420663 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A1552VC_RS16790 420653..420940 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
A1552VC_RS16795 421068..421523 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
A1552VC_RS16800 421845..421997 + 153 WP_001884520.1 DUF645 family protein -
A1552VC_RS16810 422199..422696 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
A1552VC_RS16815 422693..422965 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
A1552VC_RS16820 423196..423864 + 669 WP_000043871.1 hypothetical protein -
A1552VC_RS16825 424016..424303 + 288 WP_000426470.1 hypothetical protein -
A1552VC_RS16830 424444..424815 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
A1552VC_RS16835 424882..425307 + 426 WP_001882332.1 DUF1778 domain-containing protein -
A1552VC_RS16840 425304..425837 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
A1552VC_RS16850 426039..426296 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A1552VC_RS16855 426284..426586 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
A1552VC_RS16860 426820..427737 + 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805
flank IS/Tn - - 417013..417993 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(86-152)

Antitoxin

(7-86)


Sequences


Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T104347 WP_000982260.1 NZ_CP028895:c422696-422199 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T104347 NZ_CP028895:c422696-422199 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT104347 WP_000246253.1 NZ_CP028895:c422965-422693 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT104347 NZ_CP028895:c422965-422693 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1


Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References