Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 408431..408990 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GQX72_RS16035 Protein ID WP_000578476.1
Coordinates 408431..408709 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GQX72_RS16040 Protein ID WP_000381183.1
Coordinates 408706..408990 (-) Length 95 a.a.

Genomic Context

GQX72_RS15985GQX72_RS15990GQX72_RS15995GQX72_RS16000GQX72_RS16005GQX72_RS16010GQX72_RS16015GQX72_RS16020GQX72_RS16030GQX72_RS16045GQX72_RS16050GQX72_RS16065GQX72_RS16035GQX72_RS16040
Location: 403731..404168 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 404232..404450 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 404625..405497 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 405647..406246 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 406303..406407 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 406438..406707 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 406701..407222 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 407521..407646 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 407897..408292 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 409184..409699 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 409883..410296 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 410851..412028 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 408431..408709 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 408706..408990 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQX72_RS15985403731..404168+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
GQX72_RS15990404232..404450+219WP_071908318.1GNAT family N-acetyltransferase-
GQX72_RS15995404625..405497+873WP_000254716.1DUF3800 domain-containing protein-
GQX72_RS16000405647..406246+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GQX72_RS16005406303..406407+105WP_099607150.1acetyltransferase-
GQX72_RS16010406438..406707+270WP_001114075.1DUF4160 domain-containing protein-
GQX72_RS16015406701..407222+522WP_000921691.1DUF2442 domain-containing protein-
GQX72_RS16020407521..407646+126WP_001905700.1DUF645 family protein-
GQX72_RS16030407897..408292+396WP_001000867.1hypothetical protein-
GQX72_RS16035408431..408709-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
GQX72_RS16040408706..408990-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GQX72_RS16045409184..409699+516WP_000343779.1GNAT family N-acetyltransferase-
GQX72_RS16050409883..410296+414WP_000049420.1VOC family protein-
GQX72_RS16065410851..412028+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305960..411159105199
insideIntegron--311040..41078399743
flankIS/Tn--403731..404168437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145409 WP_000578476.1 NZ_CP047060:c408709-408431 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145409 NZ_CP062378:19747-19923 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145409 WP_000381183.1 NZ_CP047060:c408990-408706 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145409 NZ_CP062378:c20085-19911 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References