145409

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 408431..408990 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GQX72_RS16035 Protein ID WP_000578476.1
Coordinates 408431..408709 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GQX72_RS16040 Protein ID WP_000381183.1
Coordinates 408706..408990 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15985 403731..404168 + 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
GQX72_RS15990 404232..404450 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GQX72_RS15995 404625..405497 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GQX72_RS16000 405647..406246 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GQX72_RS16005 406303..406407 + 105 WP_099607150.1 acetyltransferase -
GQX72_RS16010 406438..406707 + 270 WP_001114075.1 DUF4160 domain-containing protein -
GQX72_RS16015 406701..407222 + 522 WP_000921691.1 DUF2442 domain-containing protein -
GQX72_RS16020 407521..407646 + 126 WP_001905700.1 DUF645 family protein -
GQX72_RS16030 407897..408292 + 396 WP_001000867.1 hypothetical protein -
GQX72_RS16035 408431..408709 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GQX72_RS16040 408706..408990 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GQX72_RS16045 409184..409699 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
GQX72_RS16050 409883..410296 + 414 WP_000049420.1 VOC family protein -
GQX72_RS16065 410851..412028 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743
flank IS/Tn - - 403731..404168 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145409 WP_000578476.1 NZ_CP047060:c408709-408431 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145409 NZ_CP062378:19747-19923 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145409 WP_000381183.1 NZ_CP047060:c408990-408706 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145409 NZ_CP062378:c20085-19911 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References