113811

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 214737..215315 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag EEL44_RS01520 Protein ID WP_001180243.1
Coordinates 214998..215315 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag EEL44_RS01515 Protein ID WP_000557292.1
Coordinates 214737..214979 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS01450 210131..210577 - 447 WP_000006157.1 hypothetical protein -
EEL44_RS01460 210773..210811 - 39 WP_106019118.1 hypothetical protein -
EEL44_RS01465 210827..210952 - 126 WP_001900195.1 DUF645 family protein -
EEL44_RS01470 211345..211617 + 273 WP_000246253.1 DUF1778 domain-containing protein -
EEL44_RS01475 211614..212111 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
EEL44_RS01480 212261..212776 - 516 WP_001201509.1 lipocalin family protein -
EEL44_RS01485 212913..213449 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
EEL44_RS01500 213707..213988 - 282 WP_001894429.1 DUF1289 domain-containing protein -
EEL44_RS01505 213937..214050 - 114 WP_001900214.1 hypothetical protein -
EEL44_RS01510 214107..214493 - 387 WP_001015867.1 NUDIX hydrolase -
EEL44_RS01515 214737..214979 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EEL44_RS01520 214998..215315 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EEL44_RS01530 215469..215807 - 339 WP_000713853.1 hypothetical protein -
EEL44_RS01535 215965..216669 - 705 WP_000087610.1 HNH endonuclease -
EEL44_RS01540 216831..218039 - 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
EEL44_RS01545 218201..218878 - 678 WP_000254617.1 HNH endonuclease -
EEL44_RS01555 219073..219255 - 183 WP_000923153.1 DUF645 family protein -
EEL44_RS01560 219609..219791 - 183 WP_000923340.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T113811 WP_001180243.1 NZ_CP033513:214998-215315 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T113811 NZ_CP033513:214998-215315 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT113811 WP_000557292.1 NZ_CP033513:214737-214979 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT113811 NZ_CP033513:214737-214979 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References